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Göteborgs universitets publikationer

Multiple sclerosis incidence in the era of measles-mumps-rubella mass vaccinations.

Författare och institution:
Cecilia Ahlgren (Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering); Anders Odén (Institutionen för matematiska vetenskaper, matematisk statistik, Chalmers/GU); Kjell Torén (Institutionen för medicin, avdelningen för invärtesmedicin & Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Oluf Andersen (Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering)
Publicerad i:
Acta neurologica Scandinavica, 119 ( 5 ) s. 313-20
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
BACKGROUND: Viral childhood infections may be involved in the multiple sclerosis (MS) pathogenesis. Following national Swedish vaccination programs, measles sharply declined in the 1970s, and measles, mumps, and rubella were virtually eliminated in cohorts born from 1981. OBJECTIVES: To examine whether the vaccination induced reduction in these infections influences the MS incidence. In addition, the public health aspect justified an early evaluation of beneficial as well as harmful effects of mass vaccinations. MATERIALS AND METHODS: From an incidence material of 534 MS patients, born 1959-1990, we selected one unvaccinated cohort and four cohorts, each corresponding to a vaccination program (MS patients = 251). RESULTS: With the ability to detect a decrease by 30-35%, and an increase by 37-48% in the MS incidence in the first three cohorts, we found no vaccination related MS incidence changes. The background MS incidence showed a significant gradual age dependent increase. CONCLUSIONS: While the present follow-up provided limited power in the last cohort, there is no evidence as yet that the radical decline in three viral infections influenced the MS incidence. However, the increasing background MS incidence of unknown cause may have concealed a reduction in MS risk associated with mass vaccinations.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Fysiologi ->
Age Distribution, Cohort Studies, Comorbidity, Incidence, Measles, epidemiology, prevention & control, Measles-Mumps-Rubella Vaccine, adverse effects, therapeutic use, Multiple Sclerosis, epidemiology, Mumps, epidemiology, prevention & control, Proportional Hazards Models, Risk Reduction Behavior, Rubella, epidemiology, prevention & control, Sex Distribution, Sweden, epidemiology
Postens nummer:
Posten skapad:
2009-09-22 09:16
Posten ändrad:
2016-07-18 16:16

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