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Göteborgs universitets publikationer

Hormonal regulation of longitudinal bone growth.

Författare och institution:
Anders Nilsson (Institutionen för de kirurgiska disciplinerna, Avdelningen för ortopedi); Claes Ohlsson (Institutionen för invärtesmedicin, Avdelningen för internmedicin); Olle Isaksson (Institutionen för invärtesmedicin); Anders Lindahl (Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin); Jörgen Isgaard (Institutionen för invärtesmedicin)
Publicerad i:
European journal of clinical nutrition, 48 Suppl 1 s. S150-8; discussion S158-60
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The regulation of postnatal somatic growth is complex. Genetic, nutritional factors and hormones exert regulatory functions. Hormones that have an established role in the regulation include growth hormone (GH), thyroid hormone and sex steroids. GH promotes mainly the growth of the long bones in terms of final height, while the action of the sex steroids and thyroid hormone is less well known. Longitudinal bone growth is the result of chondrocyte proliferation and subsequent endochondral ossification in the epiphyseal growth-plates. The growth-plate is a cartilaginous template that is located between the epiphysis and the metaphysis of the long bones. GH and insulin-like growth factor-I (IGF-I) have different target cells in the epiphyseal growth-plate. GH stimulates the slowly dividing prechondrocytes in the germinative cell layer while IGF-I promotes the clonal expansion in the proliferative cell layer of a GH primed cell. Thyroid hormone blocks the clonal expansion and stimulates chondrocyte maturation. IGF-I mRNA is primarily regulated by GH, and IGF-I is produced in several tissues such as the liver, muscle, fat and epiphyseal growth plates. However, IGF-I mRNA is also increased during compensatory growth of heart and kidneys and by estrogen in the Fallopian tube in the rat. Nutrition, i.e. energy from fat and carbohydrates and proteins, also influences the final height, but the cellular mechanism of action is not known. The aim of this article is to review hormonal action on longitudinal bone growth.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Animals, Bone Development, physiology, Cell Division, Epiphyses, cytology, metabolism, physiology, Gonadal Steroid Hormones, physiology, Growth Hormone, physiology, Growth Plate, physiology, Humans, Insulin-Like Growth Factor I, genetics, metabolism, Nutritional Physiological Phenomena, Osteocytes, cytology, metabolism, physiology, RNA, Messenger, Thyroid Hormones, physiology
Postens nummer:
Posten skapad:
2009-03-19 09:19
Posten ändrad:
2011-01-20 09:59

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