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Göteborgs universitets publikationer

Airway nitric oxide in patients with cystic fibrosis is associated with pancreatic function, Pseudomonas infection, and polyunsaturated fatty acids.

Författare och institution:
Christina Keen (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa); Anna-Carin Olin (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Åsa Edentoft (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa); Eva Gronowitz (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa); Birgitta Strandvik (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa)
Publicerad i:
Chest, 131 ( 6 ) s. 1857-64
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
BACKGROUND: Airway nitric oxide (NO) is low or normal in cystic fibrosis (CF) patients. This may affect bacterial status since NO has antimicrobial properties. Arachidonic acid (AA), which is increased in the serum and airways of CF patients, has been shown to reduce NO levels. The aim of this study was to investigate whether airway NO level correlates with genotype and pancreatic function, and whether low airway NO level is associated with bacterial infection and increased serum AA level in CF patients. METHOD: Nasal NO (nNO) and exhaled NO (eNO) were measured according to the European Respiratory Society/American Thoracic Society standard in 59 CF patients aged 7 to 55 years, 80% of whom were pancreatic insufficient (PI) and 51% were chronically infected with Pseudomonas aeruginosa. RESULTS: PI CF patients had significantly lower nNO levels than pancreatic-sufficient (PS) patients. Airway NO level did not correlate with lung function or inflammatory parameters. PI patients chronically infected with P aeruginosa had significantly lower nNO levels than noninfected PI patients. nNO level correlated inversely with the AA/docosahexaenoic acid ratio, and eNO with the essential fatty acid (FA) deficiency index, which is the ratio between mead acid and AA. CONCLUSIONS: CF patients with PI, which is associated with more severe genotypes, had lower airway NO levels than patients with PS. Low NO level was correlated to chronic P aeruginosa infection, and an association was found between airway NO level and the abnormal serum phospholipid FA pattern.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Mikrobiologi inom det medicinska området
Adolescent, Adult, Arachidonic Acid, blood, Breath Tests, Child, Cystic Fibrosis, complications, genetics, metabolism, Cystic Fibrosis Transmembrane Conductance Regulator, genetics, metabolism, Exocrine Pancreatic Insufficiency, metabolism, Fatty Acids, Essential, blood, Fatty Acids, Unsaturated, blood, Female, Genotype, Humans, Male, Middle Aged, Nasal Cavity, chemistry, Nitric Oxide, analysis, metabolism, Pseudomonas Infections, metabolism, Pseudomonas aeruginosa, pathogenicity
Postens nummer:
Posten skapad:
2009-01-16 15:52
Posten ändrad:
2010-11-15 17:59

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