transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1.

Författare och institution:
Bob Olsson (Institutionen för medicin, avdelningen för invärtesmedicin); Börje Ridell (Institutionen för biomedicin, avdelningen för patologi); Lena M S Carlsson (Institutionen för medicin, avdelningen för molekylär och klinisk medicin); Stefan Jacobsson (Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin); Hans Wadenvik (Institutionen för medicin, avdelningen för invärtesmedicin)
Publicerad i:
Blood, 112 ( 4 ) s. 1078-84
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
In idiopathic thrombocytopenic purpura (ITP), platelets are destroyed in the spleen, liver, and bone marrow (BM) by autoantibodies and cytotoxic T cells. In a DNA microarray screen of peripheral blood T cells, we found that VLA-4, CX3CR1, and CXCR4, involved in T-cell homing, had increased expression in ITP patients compared with controls. However, we only found increased protein expression of VLA-4 on T cells from peripheral blood by flow cytometry. To address a possible recruitment of T cells into the organs involved in platelet destruction, we analyzed T cells in BM. In BM, T-cell surface expression of VLA-4 and CX3CR1 was increased in ITP patients compared with controls. Furthermore, the number of CD3(+) T cells in BM, but not in blood, was increased in ITP patients compared with controls. This finding was confirmed by immunohistochemistry of BM biopsies. The number of regulatory T cells (CD4(+)/CD25(bright)) was decreased in the BM of ITP patients, whereas Fas expression was increased. In conclusion, ITP is associated with accumulation and activation of T cells in the BM. Recruitment of T cells into the target organ (eg, BM) is plausible and may be facilitated through increased VLA-4 and CX3CR1 expression. These molecules might serve as new treatment targets in ITP.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Adolescent, Adult, Aged, Bone Marrow, pathology, Cell Movement, Female, Gene Expression Profiling, Humans, Immunity, Integrin alpha4beta1, genetics, Male, Middle Aged, Purpura, Thrombocytopenic, Idiopathic, immunology, Receptors, CXCR4, genetics, Receptors, Chemokine, genetics, T-Lymphocyte Subsets, T-Lymphocytes, physiology, Up-Regulation, genetics
Postens nummer:
Posten skapad:
2009-01-16 10:38
Posten ändrad:
2011-01-20 10:00

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007