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Göteborgs universitets publikationer

Increased CSF-BACE 1 activity is associated with ApoE-epsilon 4 genotype in subjects with mild cognitive impairment and Alzheimer's disease.

Författare och institution:
Michael Ewers (-); Zhenyu Zhong (-); Katharina Bürger (-); Anders Wallin (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Kaj Blennow (Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi); Stefan J Teipel (-); Yong Shen (-); Harald Hampel (-)
Publicerad i:
Brain : a journal of neurology, 131 ( Pt 5 ) s. 1252-8
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The Apolipoprotein (ApoE) epsilon 4 allele is a major genetic risk factor of Alzheimer's disease, and may affect the production of amyloid beta (A beta(1-42)). Recently, we have shown that beta-secretase (BACE 1) activity can be reliably detected within the brain and human CSF. Here, we have examined an association between the ApoE genotype and CSF-levels of BACE 1 activity in Alzheimer's disease and mild cognitive impairment (MCI). A total of 148 subjects were included: 60 Alzheimer's disease patients, 51 MCI subjects and 37 elderly healthy controls. The CSF-levels of A beta(1-42), BACE 1 activity and BACE protein were measured in all of these subjects. The differences between ApoE-epsilon 4 carriers and ApoE-epsilon 4 non-carriers in these CSF-based measures were determined controlling for gender, age and MMSE score. The ApoE-epsilon 4 genotype was associated with increased BACE 1 activity in both Alzheimer's disease (P = 0.03) and MCI (P = 0.04) subjects. Levels of A beta(1-42) were decreased in ApoE-epsilon 4 carriers in MCI (P = 0.004) but not Alzheimer's disease subjects. This study is the first to demonstrate the association between ApoE-epsilon 4 and CSF-BACE 1 activity in MCI and Alzheimer's disease subjects. The assessment of BACE 1 in CSF may provide a sensitive measure to detect in vivo alterations in the amyloidogenic processing potentially modified by the ApoE genotype.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Aged, Aged, 80 and over, Alzheimer Disease, cerebrospinal fluid, genetics, Amyloid Precursor Protein Secretases, cerebrospinal fluid, Amyloid beta-Protein, cerebrospinal fluid, Apolipoproteins E, genetics, Aspartic Endopeptidases, cerebrospinal fluid, Biological Markers, cerebrospinal fluid, Cognition Disorders, cerebrospinal fluid, genetics, Female, Genotype, Humans, Male, Middle Aged, Peptide Fragments, cerebrospinal fluid
Postens nummer:
Posten skapad:
2009-01-16 09:01

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