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Göteborgs universitets publikationer

The GH/IGF-1 Axis in Obesity: Physiological and Pathological Aspects.

Författare och institution:
Celina Franco Ramos (Institutionen för medicin, avdelningen för invärtesmedicin); Bengt-Åke Bengtsson (Institutionen för medicin, avdelningen för invärtesmedicin); Gudmundur Johannsson (Institutionen för medicin, avdelningen för invärtesmedicin)
Publicerad i:
Metabolic syndrome and related disorders, 4 ( 1 ) s. 51-6
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The cluster of cardiovascular risk factors-abdominal obesity, dyslipidaemia, insulin resistance and hypertension-has been recognized as the core of the metabolic syndrome. Adults with severe growth hormone (GH) deficiency have, to a large extent, features of the metabolic syndrome, and there is a strong inverse association between visceral fat accumulation and blunted GH secretion in adults. Hyposomatotropism in abdominal obesity has therefore been suggested to be of importance for its metabolic consequences. However, the underlying pathophysiological mechanisms are poorly understood. Prevalence of the metabolic syndrome is steadily increasing worldwide. Overnutrition and sedentary habits are the stigmata of modern society that predispose genetically susceptible individuals to develop central obesity and other features of the metabolic syndrome including glucose intolerance, hypertension and dyslipidemia. Although there are still no unified definitions of the syndrome, it is clear that this condition is associated with an increased risk for development of cardiovascular disease (CVD) and diabetes mellitus (DM). In this review, we discuss current evidence regarding alterations in the GH-IGF- 1 axis in abdominal obesity and its possible impact on other features of the metabolic syndrome.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Postens nummer:
Posten skapad:
2009-01-15 22:07
Posten ändrad:
2011-01-20 09:59

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