|Göteborgs universitets publikationer
Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.
Författare och institution:
Maria Elfving (-); Johan Svensson (Institutionen för medicin, avdelningen för invärtesmedicin); Sami Oikarinen (-); Björn Jonsson (-); Per Olofsson (-); Göran Sundkvist (-); Bengt Lindberg (-); Ake Lernmark (-); Heikki Hyöty (-); Sten-Anders Ivarsson (-)
Experimental diabetes research, 2008 s. 271958
Artikel, refereegranskad vetenskaplig
Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22-17.6), as compared to boys of IgM-negative mothers (P < .025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP
Adolescent, Adult, Age of Onset, Child, Preschool, Diabetes Mellitus, Type 1, epidemiology, genetics, virology, Enterovirus, genetics, isolation & purification, Enterovirus Infections, complications, Female, Fetal Blood, physiology, virology, Genetic Predisposition to Disease, Humans, Infant, Newborn, Male, Polymerase Chain Reaction, Pregnancy, Pregnancy Complications, virology, Risk Factors, Sweden, epidemiology