|Göteborgs universitets publikationer
Immigration and the incidence of Graves thyrotoxicosis, thyrotoxic multinodular goitre and solitary toxic adenoma.
Författare och institution:
M Lantz (-); M Abraham-Nordling (-); Johan Svensson (Institutionen för medicin, avdelningen för invärtesmedicin); G. Wallin (-); Bengt Hallengren (-)
European journal of endocrinology / European Federation of Endocrine Societies,
Artikel, refereegranskad vetenskaplig
Objective: Environmental and genetic factors influence thyrotoxicosis but how population migration affects the disease panorama is not known. In an urban area in southern Sweden, during the years 1990 until 2003, the population increased from 232 000 to 267 000. In parallell the proportion of inhabitants born outside Sweden increased. The aim was to investigate whether the incidence of Graves thyrotoxicosis (GD), toxic multinodular goitre (TMNG) and solitary toxic adenoma (STA) has changed in Malmoe since 1990 and to study the influence of geographic origin. Design and method: Open label prospective registration of thyrotoxicosis, gender, age, smoking habits and geographic background during 2003-2005 in an urban area in southern Sweden. Results: The total incidence of thyrotoxicosis has changed from 43 to 41.6 cases/100 000/year from the years 1988-1990 to 2003-2005 (p-value 0.72). GD increased from 22 to 29.6 (p-value 0.0051), TMNG decreased from 16 to 9.9 (p-value 0.0011) and STA from 4.8 to 2.1 (p-value 0.0054) /100 000/year. The incidence of GD was higher in inhabitants born outside Sweden up to the age 69 years and age-specific incidence showed a peak in women 50-59 years old in both groups. Conclusion: The incidence of GD has increased and of TMNG has decreased in Malmoe since 1990. Geographic origin seems to affect the incidence in GD. Whether the observed peak in age-related incidence in women 50-59 years is explained by menopausal changes has to be further investigated.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP