transparent gif


Ej inloggad.

Göteborgs universitets publikationer

CD4+ CD25high regulatory T cells reduce T cell transendothelial migration in cancer patients.

Författare och institution:
Karin Enarsson (Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi); Samuel B Lundin (Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi); Erik Johnsson (Institutionen för kliniska vetenskaper, sektionen för kirurgi och kirurgisk gastroforskning); Thomas Brezicka (Institutionen för kliniska vetenskaper); Marianne Quiding-Järbrink (Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi)
Publicerad i:
European journal of immunology, 37 ( 1 ) s. 282-91
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Cell-mediated immunity is thought to be the main mechanism of anti-tumour responses of the host, but it is not known if cancer disease affects T cell recruitment from blood to tissues. Therefore, we compared Heliobacter pylori-induced T cell transendothelial migration (TEM) in H. pylori-infected gastric carcinoma patients, colon and lung carcinoma patients and healthy volunteers. H. pylori induced significant T cell migration from all groups. However, there was a dramatic reduction of T cell TEM in gastric carcinoma patients (80%) compared to healthy individuals. A similarly reduced transmigration was also seen in colon and lung carcinoma patients. We found significantly increased frequencies of T(reg) cells in the blood of gastric carcinoma patients compared to healthy individuals, and depletion of T(reg) cells from the blood of these patients prior to TEM restored T cell migration. The effect of T(reg) cells was largely dependent on cell-cell contact, but not on IL-10 or TGF-beta. In addition, the presence of T(reg) cells led to reduced T cell attachment to endothelium and decreased production of T cell-recruiting chemokines during TEM. In conclusion, T(reg) cell-mediated reduction of T cell TEM may reduce T cell recruitment in patients with epithelial malignancies, thereby hampering anti-tumour responses.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Immunologi inom det medicinska området
Adult, Aged, Aged, 80 and over, Carcinoma, Non-Small-Cell Lung, immunology, pathology, Cell Adhesion, immunology, Cell Migration Inhibition, Cell Movement, immunology, Colonic Neoplasms, immunology, pathology, Contact Inhibition, immunology, Endothelium, Vascular, cytology, immunology, metabolism, Female, Helicobacter pylori, immunology, Humans, Interleukin-2 Receptor alpha Subunit, biosynthesis, Lung Neoplasms, immunology, pathology, Male, Middle Aged, Stomach Neoplasms, immunology, pathology, T-Lymphocytes, Regulatory, immunology, metabolism, pathology
Postens nummer:
Posten skapad:
2009-01-09 15:02
Posten ändrad:
2011-01-20 09:59

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007