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Göteborgs universitets publikationer

Mouse chromosome 19 and distal rat chromosome 1: a chromosome segment conserved in evolution.

Författare och institution:
Y Yamasaki (-); Khalil Helou (Institutionen för särskilda specialiteter, Avdelningen för onkologi); T K Watanabe (-); Åsa Sjöling (Institutionen för cell- och molekylärbiologi, genetik); M Suzuki (-); S Okuno (-); T Ono (-); T Takagi (-); Y Nakamura (-); Fredrik Ståhl (Institutionen för cell- och molekylärbiologi, genetik); A Tanigami (-)
Publicerad i:
Hereditas, 134 ( 1 ) s. 23-34
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Through a combination of radiation hybrid mapping and studies by FISH and zoo-FISH we have made a comparative investigation of the distal portion of rat chromosome 1 (RNO1) and the entire mouse chromosome 19 (MMU19). It was found that homologous segments of RNO1 and MMU19 are similar in banding morphology and in length as determined by several different methods, and that the gene order of the 46 genes studied appears to be conserved across the homologous segments in the two species. High-resolution zoo-FISH techniques showed that MMU19 probes highlight only a continuous segment on RNO1 (1q43-qter), with no detectable signals on other rat chromosomes. We conclude that these data suggest the evolutionary conservation of a chromosomal segment from a common rodent ancestor. This segment now constitutes the entire MMU19 and a large segment distally on RNO1q in the mouse and rat, respectively.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Biologiska vetenskaper
Animals, Cells, Cultured, Chromosome Mapping, Chromosomes, genetics, ultrastructure, Evolution, Molecular, In Situ Hybridization, Fluorescence, Mice, genetics, Phylogeny, Quantitative Trait, Heritable, Radiation Hybrid Mapping, Rats, genetics, Rodentia, classification, genetics, Species Specificity
Postens nummer:
Posten skapad:
2009-01-07 15:26
Posten ändrad:
2011-01-20 10:00

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