Continuing intrathecal immunoactivation despite two years of effective antiretroviral therapy against HIV-1 infection
Författare och institution:
Sahra Abdulle (Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar); Lars Hagberg (Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar); Bo Svennerholm (Institutionen för laboratoriemedicin, Avdelningen för klinisk virologi); Dietmar Fuchs (-); Magnus Gisslén (Institutionen för invärtesmedicin, Avdelningen för infektionssjukdomar)
Publicerad i:
Aids, 16 ( 16 ) s. 2145-9
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2002
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
OBJECTIVE: To study the effect of antiretroviral combination treatment on intrathecal immunoactivation in HIV-1 infection. METHOD: Lumbar punctures were performed at baseline, and after 4 months, 1 and 2 years on 30 neurologically asymptomatic, treatment-naive HIV-1-infected patients started on antiretroviral treatment with three or more drugs. Levels of neopterin, beta2-microglobulin and HIV-1 RNA were measured in cerebrospinal fluid (CSF) and blood. RESULTS: All patients continued the study until the 4-month follow-up, although seven discontinued before the 1-year control, and an additional five discontinued before the control after 2 years. Neopterin, beta2-microglobulin and HIV-1 RNA decreased significantly both in CSF and blood, but although 100% of the patients decreased their CSF concentrations of beta2-microglobulin and HIV-1 RNA to normal levels, only 55% had normal CSF neopterin concentrations after 2 years treatment. CONCLUSIONS: In addition to CSF viral load, antiretroviral combination therapy substantially decreases the intrathecal immunoactivation as reflected by CSF neopterin and beta2-microglobulin in neuroasymptomatic HIV-1-infected patients. However, almost half of the patients still have slightly increased CSF neopterin concentrations after 2 years of effective treatment, which might reflect an ongoing low-grade viral replication in brain tissue.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper ->
Mikrobiologi inom det medicinska området
Medicinska grundvetenskaper ->
Mikrobiologi inom det medicinska området
Nyckelord:
Adult, Anti-HIV Agents/*therapeutic use, Drug Combinations, Female, HIV Infections/blood/cerebrospinal fluid/*drug therapy, Humans, Male, Middle Aged, Neopterin/blood/cerebrospinal fluid, RNA, Viral/blood/cerebrospinal fluid, Viral Load, beta 2-Microglobulin/blood/cerebrospinal fluid
Postens nummer:
83668
Posten skapad:
2009-01-06 17:55
Posten ändrad:
2011-01-20 10:00