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The peptide AF-16 abolishes sickness and death at experimental encephalitis by reducing increase of intracranial pressure.

Författare och institution:
Eva Jennische (Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi); Tomas Bergström (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Maria Johansson (Institutionen för biomedicin); Kristina Nyström (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Andrej Tarkowski (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Hans-Arne Hansson (Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi); Stefan Lange (Institutionen för biomedicin, avdelningen för infektionssjukdomar)
Publicerad i:
Brain research, 1227 s. 189-97
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Elevated intracranial pressure (ICP) is strongly aggravating the injury at brain inflammation, resulting in persistent neurological and psychiatric malfunctions. There is no efficient pharmacological treatment to achieve beneficial ICP reduction. Here, the peptide AF-16, comprising the amino terminal part of the endogenous protein Antisecretory Factor (AF), was used to suppress the raised ICP in experimental herpes simplex encephalitis (HSE) in rats. Intranasal instillation of the peptide AF-16 counteracted the ICP elevation and the prevalence of ICP spikes, abrogated the neurological morbidity, and abolished the mortality in a dose-dependent manner. AF-16, 25 microg twice daily intranasally, rescued all animals with HSE and abrogated neurological malfunction. In contrast, only 10% of the rats survived if treated with the vehicle. A single intranasal dose of 25 microg AF-16 to a rat displaying overt HSE symptoms reduced the ICP to normal levels within an hour. No effects on viral replication or antigen distribution were demonstrable. Thus, AF-16 abolished the prevalence of sickness signs, ICP elevation, neurological malfunctions and completely prevented deaths. We advocate use of AF-16 for suppression of elevated ICP.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Mikrobiologi inom det medicinska området
Administration, Intranasal, Animals, Antidiarrheals, administration & dosage, therapeutic use, Brain, drug effects, pathology, physiopathology, Cells, Cultured, Dose-Response Relationship, Drug, Encephalitis, Herpes Simplex, drug therapy, physiopathology, virology, Herpesvirus 1, Human, genetics, metabolism, Humans, Immunohistochemistry, Intracranial Hypertension, drug therapy, physiopathology, Intracranial Pressure, drug effects, physiology, Male, Neurons, drug effects, pathology, virology, Neuropeptides, administration & dosage, therapeutic use, Peptides, administration & dosage, therapeutic use, Polymerase Chain Reaction, Rats, Rats, Sprague-Dawley, Treatment Outcome
Postens nummer:
Posten skapad:
2008-12-22 19:52
Posten ändrad:
2013-07-01 14:45

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