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Göteborgs universitets publikationer

Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1.

Författare och institution:
Helena Forsblad d'Elia (Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning); Lars-Åke Mattsson (Institutionen för kvinnors och barns hälsa, Avdelningen för obstetrik och gynekologi); Claes Ohlsson (Institutionen för invärtesmedicin, Avdelningen för internmedicin); Elisabeth Nordborg (Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning); Hans Carlsten (Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning)
Publicerad i:
Arthritis research & therapy, 5 ( 4 ) s. R202-9
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Hormone replacement therapy (HRT) modulates the imbalance in bone remodeling, thereby decreasing bone loss. Sex hormones are known to influence rheumatic diseases. The aim of this study was to investigate the effects of HRT on the serum levels of hormones and cytokines regulating bone turnover in 88 postmenopausal women with active rheumatoid arthritis (RA) randomly allocated to receive HRT plus calcium and vitamin D3 or calcium and vitamin D3 alone for 2 years. An increase in estradiol (E2) correlated strongly with improvement of bone mineral density in the hip (P < 0.001) and lumbar spine (P < 0.001). Both baseline levels and changes during the study of IL-6 and erythrocyte sedimentation rate were correlated positively (P < 0.001). HRT for 2 years resulted in an increase of the bone anabolic factor, insulin-like growth factor 1 (IGF-1) (P < 0.05) and a decrease of serum levels of soluble IL-6 receptor (sIL-6R) (P < 0.05), which is known to enhance the biological activity of IL-6, an osteoclast-stimulating and proinflammatory cytokine. Baseline levels of IL-6 and IGF-1 were inversely associated (P < 0.05), and elevation of IGF-1 was connected with decrease in erythrocyte sedimentation rate (P < 0.05) after 2 years. Interestingly, increase in serum levels of E2 was associated with reduction of sIL-6R (P < 0.05) and reduction of sIL-6R was correlated with improved bone mineral density in the lumbar spine (P < 0.05). The latter association was however not significant after adjusting for the effect of E2 (P = 0.075). The influences of IGF-1 and the IL-6/sIL-6R pathways suggest possible mechanisms whereby HRT may exert beneficial effects in RA. However, to confirm this hypothesis future and larger studies are needed.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Aged, Arthritis, Rheumatoid, blood, Cytokines, blood, Estrogen Replacement Therapy, Female, Follow-Up Studies, Glycoproteins, blood, Humans, Insulin-Like Growth Factor I, analysis, Middle Aged, Osteoprotegerin, Receptors, Cytoplasmic and Nuclear, blood, Receptors, Interleukin-6, blood, Receptors, Tumor Necrosis Factor
Postens nummer:
Posten skapad:
2008-12-12 14:17
Posten ändrad:
2011-01-20 09:58

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