transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Changes in neurogenesis in dementia and Alzheimer mouse models: are they functionally relevant?

Författare och institution:
Hans-Georg Kuhn (Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering); Christiana M Cooper-Kuhn (Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering); Karin Boekhoorn (-); Paul J Lucassen (-)
Publicerad i:
European archives of psychiatry and clinical neuroscience, 257 ( 5 ) s. 281-9
Artikel, forskningsöversikt
Sammanfattning (abstract):
Alzheimer's disease and related dementias are devastating disorders that lead to the progressive decline of cognitive functions. Characteristic features are severe brain atrophy, paralleled by accumulation of beta amyloid and neurofibrillary tangles. With the discovery of neurogenesis in the adult brain, the hopes have risen that these neurodegenerative conditions could be overcome, or at least ameliorated, by the generation of new neurons. The location of the adult neurogenic zones in the hippocampus and the lateral ventricle wall, close to corpus callosum and neocortex, indicates strategic positions for potential repair processes. However, we also need to consider that the generation of new neurons is possibly involved in cognitive functions and could, therefore, be influenced by disease pathology. Moreover, aberrant neurogenic mechanisms could even be a part of the pathological events of neurodegenerative diseases. It is the scope of this review to summarize and analyze the recent data from neurogenesis research with respect to Alzheimer's disease and its animal models.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Neurovetenskaper ->
Alzheimer Disease, pathology, prevention & control, Animals, Brain, pathology, Cell Cycle Proteins, metabolism, Dementia, pathology, prevention & control, Disease Models, Animal, Environment, Hippocampus, pathology, Humans, Mice, Neurons, pathology, tau Proteins, biosynthesis, genetics
Postens nummer:
Posten skapad:
2008-11-23 16:26
Posten ändrad:
2011-01-20 09:59

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007