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The influence of food on the pharmacokinetics of piperaquine in healthy Vietnamese volunteers.

Författare och institution:
Trinh Ngoc Hai (-); Sofia Friberg Hietala (Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi); Nguyen Van Huong (-); Michael Ashton (Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi)
Publicerad i:
Acta tropica, 107 ( 2 ) s. 145-9
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The combination piperaquine and dihydroartemisinin is emerging as first line treatment of uncomplicated falciparum malaria in Southeast Asia. The aim of this study was to determine the influence of a standard Vietnamese meal on the single-dose pharmacokinetics of piperaquine when administered in combination with dihydroartemisinin, and to gain extended data on the terminal half-life of piperaquine in healthy Vietnamese volunteers. Subjects were randomly assigned to take a single oral dose of piperaquine phosphate (640 mg)+dihydroartemisinin (80 mg) together with a standardized Vietnamese meal (n=16) or to remain fasting for 4h following drug intake (n=16). Frequent blood sampling was conducted during 36 h, followed by weekly samples for 7 weeks. The pharmacokinetic parameters of piperaquine were determined by noncompartmental analysis. The median (80% central range) AUC(0-last) was 11.5 (6.9-17.3)h mg/L in fed and 13.9 (2.8-19.3)h mg/L in fasting subjects, indicating a considerable variability in exposure in both groups. The estimated overall oral clearance was 0.27 (0.12-1.49)L/(h kg), the volume of distribution during the terminal elimination phase was 230 (102-419)L/kg and estimated terminal half-life was 18 (5-93) days. This study did not demonstrate a significant impact of a standardized Vietnamese meal on the oral absorption of piperaquine.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Farmaceutisk vetenskap ->
Administration, Oral, Adult, Antimalarials, administration & dosage, pharmacokinetics, Area Under Curve, Artemisinins, administration & dosage, Biological Availability, Drug Therapy, Combination, Fasting, Female, Food-Drug Interactions, Humans, Male, Meat, Middle Aged, Ovum, Quinolines, administration & dosage, pharmacokinetics, Vegetables, Vietnam, Voluntary Workers
Postens nummer:
Posten skapad:
2008-10-28 12:34
Posten ändrad:
2010-04-16 09:44

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