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Göteborgs universitets publikationer

Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue

Författare och institution:
Louise Nilsson (Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi); Nadine Binart (-); Mohammad Bohlooly-Yeganeh (-); Margareta Bramnert (-); Emil Egecioglu (Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi); Jon Kindblom (Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi); Paul Kelly (-); John J Kopchick (-); Christopher Ormandy (-); Charlotte Ling (-); Håkan Billig (Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi)
Publicerad i:
Biochemical and Biophysical Research Communications, 331 s. 1120–1126
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Adiponectin is a hormone secreted from adipose tissue, and serum levels are decreased with obesity and insulin resistance. Because prolactin (PRL) and growth hormone (GH) can affect insulin sensitivity, we investigated the effects of these hormones on the regulation of adiponectin in human adipose tissue in vitro and in rodents in vivo. Adiponectin secretion was significantly suppressed by PRL and GH in in vitro cultured human adipose tissue. Furthermore, PRL increased adiponectin receptor 1 (AdipoR1) mRNA expression and GH decreased AdipoR2 expression in the cultured human adipose tissue. In transgenic mice expressing GH, and female mice expressing PRL, serum levels of adiponectin were decreased. In contrast, GH receptor deficient mice had elevated adiponectin levels, while PRL receptor deficient mice were unaffected. In conclusion, we demonstrate gene expression of AdipoR1 and AdipoR2 in human adipose tissue for the first time, and show that these are differentially regulated by PRL and GH. Both PRL and GH reduced adiponectin secretion in human adipose tissue in vitro and in mice in vivo. Decreased serum adiponectin levels have been associated with insulin resistance, and our data in human tissue and in transgenic mice suggest a role for adiponectin in PRL and GH induced insulin resistance.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Adiponectin; Adiponectin receptor; Prolactin; Growth hormone
Postens nummer:
Posten skapad:
2008-10-15 10:17
Posten ändrad:
2010-01-26 12:48

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