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Göteborgs universitets publikationer

Metabolic functions of liver-derived (endocrine) insulin-like growth factor I.

Författare och institution:
Olle Isaksson (Institutionen för invärtesmedicin); John-Olov Jansson (Institutionen för invärtesmedicin); Klara Sjögren (Institutionen för invärtesmedicin, Avdelningen för internmedicin); Claes Ohlsson (Institutionen för invärtesmedicin, Avdelningen för internmedicin)
Publicerad i:
Hormone research, 55 Suppl 2 s. 18-21
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Until now it has been difficult to determine the relative importance of locally produced (autocrine/paracrine) versus systemically derived (endocrine) insulin-like growth factor I (IGF-I) in the intact organism. We recently eliminated IGF-I production in the livers of mice using the Cre/loxP recombination system. These mice displayed a reduction in serum IGF-I levels of more than 80%, but demonstrated normal body growth, suggesting that autocrine/paracrine-acting IGF-I, but not endocrine-acting IGF-I, regulates body growth. Long-term metabolic studies of mice in which IGF-I production had been inactivated in the liver, have shown that the mice have decreased fat mass, but increased serum levels of insulin and cholesterol. Despite the marked increase in plasma insulin following glucose administration, the glucose elimination was not altered in these animals. Thus, the mice showed an adequately compensated insulin resistance. In conclusion, liver-derived or endocrine IGF-I is not required for post-natal statural growth, but seems to be of vital importance for normal carbohydrate and lipid metabolism.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Animals, Body Composition, physiology, Endocrine Glands, metabolism, Insulin Resistance, physiology, Insulin-Like Growth Factor I, metabolism, Liver, metabolism, Mice
Postens nummer:
Posten skapad:
2008-10-14 11:30
Posten ändrad:
2011-01-20 09:59

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