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Göteborgs universitets publikationer

IL6 and IL1B polymorphisms are associated with fat mass in older men: the MrOS Study Sweden.

Författare och institution:
Louise Strandberg (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Dan Mellström (Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa); Osten Ljunggren (-); Elin Grundberg (-); Magnus K Karlsson (-); Anna H Holmberg (-); Eric S Orwoll (-); Anna-Lena Eriksson (Institutionen för medicin, avdelningen för invärtesmedicin); Johan Svedberg (-); Magnus Bengtsson (-); Claes Ohlsson (Institutionen för medicin, avdelningen för invärtesmedicin); John-Olov Jansson (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi)
Publicerad i:
Obesity (Silver Spring, Md.), 16 ( 3 ) s. 710-3
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
There is growing evidence that immune functions are linked to the regulation of body fat. Our studies of knockout mice indicate that both endogenous interleukin (IL)-6 and IL-1 can suppress mature-onset obesity. We now investigated whether four common polymorphisms of the IL6 and IL1 systems are associated with the fat mass measured with dual-energy X-ray absorptiometry (DXA) in elderly men (n = 3,014). The study subjects were from the Swedish part of the MrOS multicenter population study and 69-81 years of age. The IL6 -174 G>C (Minor allele frequency (MAF) = 48%) gene promoter polymorphism was associated with the primary outcome total fat mass (P = 0.006) and regional fat masses, but not with lean body mass. The IL1B -31T>C (MAF = 34%) polymorphism was also associated with total fat (P = 0.007) and regional fat masses, but not lean body mass. The IL-1 receptor antagonist (IL-1ra) gene (IL1RN) +2018 T>C (MAF = 27%) polymorphism (in linkage disequilibrium (LD) with a well-studied variable number tandem repeat of 86 base pair (bp)) and IL1B +3953 C>T (MAF = 26%) polymorphism were not associated with total fat mass. In conclusion, the IL-1 and IL-6 systems, shown to suppress mature-onset obesity in experimental animals, contain gene polymorphisms that are associated with fat, but not lean, mass in elderly men.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Absorptiometry, Photon, Adiposity, genetics, Aged, Aged, 80 and over, Base Pairing, Body Mass Index, Gene Frequency, Genotype, Humans, Interleukin 1 Receptor Antagonist Protein, genetics, Interleukin-1beta, genetics, Interleukin-6, genetics, Linkage Disequilibrium, Male, Minisatellite Repeats, Models, Genetic, Peptide Fragments, genetics, Phenotype, Polymorphism, Single Nucleotide, Promoter Regions (Genetics), Prospective Studies, Sweden, Thinness, genetics
Postens nummer:
Posten skapad:
2008-10-09 14:12
Posten ändrad:
2013-10-31 07:00

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