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Göteborgs universitets publikationer

Influence of cold ischemia time on complement activation, neopterin, and cytokine release in liver transplantation.

Författare och institution:
Annette Schmidt (Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård); H Tomasdottir (-); Anders Bengtsson (Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård)
Publicerad i:
Transplantation proceedings, 36 ( 9 ) s. 2796-8
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
OBJECTIVES: The aim of this study was to determine whether a cold ischemia time (CIT) of >12 hours influences the activation of complement as well as the plasma concentrations of neopterin, interleukin (IL)-6, or IL-8 in orthotopic liver transplantation (OLT). PATIENTS AND METHODS: Eighteen consecutive patients undergoing OLT using a veno-venous bypass technique were divided into 2 groups: duration of CIT >12 hours (group 1; n = 11), and CIT <12 hours (group 2; n = 7). Blood samples were drawn preoperatively, 1 minute before, and 120 minutes after reperfusion. RESULTS: Preoperatively, complement split products, neopterin, IL-6, and IL-8 levels did not differ between the groups. At 120 minutes after reperfusion, the concentrations of C3a, SC5b-9, neopterin, IL-6, and IL-8 were significantly increased in both groups compared with the preoperative values or the levels determined 1 minute before reperfusion (P < .05). Patients in group 1 showed significantly higher IL-8 levels at 120 minutes after reperfusion (P < .05). CONCLUSION: Complement is activated and pro-inflammatory cytokines released after reperfusion in OLT using a veno-venous bypass technique, but only IL-8 plasma levels were influenced by the duration of CIT. Therefore, alterations following prolonged CIT seem to not be complement-mediated.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Cold, Complement Activation, Cytokines, secretion, Humans, Interleukins, blood, Ischemia, Liver, Liver Transplantation, immunology, Neopterin, blood, Organ Preservation, Time Factors
Postens nummer:
Posten skapad:
2007-12-13 09:58

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