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Göteborgs universitets publikationer

Lung function decline, chronic bronchitis, and occupational exposures in young adults

Författare och institution:
Jordi Sunyer (-); J. P. Zock (-); H. Kromhout (-); R. Garcia-Esteban (-); K. Radon (-); D. Jarvis (-); Kjell Torén (Institutionen för invärtesmedicin); N. Kunzli (-); D. Norback (-); A. d'Errico (-); I. Urrutia (-); F. Payo (-); M. Olivieri (-); S. Villani (-); M. Van Sprundel (-); J. M. Anto (-); M. Kogevinas (-)
Publicerad i:
Am J Respir Crit Care Med, 172 ( 9 ) s. 1139-45.
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Rationale: Occupational exposures to vapors, gas, dust, or fumes have been shown to be a risk factor of airway obstruction in cross-sectional studies in the general population.Objectives: Our aim was to study the relationships between specific occupations and occupational exposures during a 9-yr follow-up period and changes in lung function and symptoms of chronic bronchitis.Methods: Subjects from the general population aged 20 to 45 yr were randomly selected in 1991-1993 within the European Community Respiratory Health Survey. Follow-up took place from 1998 to 2002 among 4,079 males and 4,461 females in 27 study centers. A total of 3,202 men and 3,279 women twice completed lung function measurements. Job history during follow-up was linked to a job exposure matrix and consequently translated into cumulative exposure estimates.Main Results: Individuals exposed to dusts, gases, and fumes during the period of follow-up did not have a steeper decline of FEV(1) than did individuals with consistently white-collar occupations without occupational exposures (relative change among men and women, + 1.4 and -3.1 ml/yr, respectively; p > 0.2), nor an increase of prevalence or incidence of airway obstruction defined as an FEV(1)/FVC ratio of less than 0.7. The incidence of chronic phlegm increased in men exposed to mineral dust (relative risk, 1.94 [1.29-2.91]) and gases and fumes (relative risk, 1.53 [0.99-2.36]), which was not modified by smoking.Conclusion: Occupational exposures to dusts, gases, and fumes occurring during the 1990s are associated with incidence of chronic bronchitis, although these did not impair lung function in a population of relatively young age.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Lungmedicin och allergi
Postens nummer:
Posten skapad:
2007-11-20 13:32
Posten ändrad:
2010-01-26 11:05

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