|Göteborgs universitets publikationer
Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells.
Författare och institution:
Zhi-Hong Chi (-); Xin Wang (-); Zhan-You Wang (-); Hui-Ling Gao (-); Annica Dahlström (Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi); Liping Huang (-)
Neuroreport, 17 ( 17 ) s. 1807-11
Artikel, refereegranskad vetenskaplig
The cellular localization of zinc transporter 7 protein in the mouse choroid plexus was examined in this study. Zinc transporter 7 immunoreactive cells were detected in the third, lateral, and fourth ventricles of CD-1 mouse brain. Distinct zinc transporter 7 immunoreactivity was concentrated in the perinuclear regions of the positive cells. The results from zinc autometallography showed that zinc-positive grains were also predominantly located in the perinuclear areas. Ultrastructural localization showed that zinc transporter 7 immunostaining was predominantly present in the membrane and cisternae of the cis-Golgi networks and some vesicle compartments. The results support the notion that zinc transporter 7 may participate in the transport of the cytoplasmic zinc into the Golgi apparatus, and may be involved in local packaging of zinc-binding proteins in the mouse choroid plexus.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
MEDICIN OCH HÄLSOVETENSKAP
Animals, Carrier Proteins, metabolism, Choroid Plexus, cytology, Epithelial Cells, ultrastructure, Golgi Apparatus, metabolism, Immunohistochemistry, methods, Male, Mice, Microscopy, Electron, Transmission, methods