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Göteborgs universitets publikationer

The developing mouse thyroid: embryonic vessel contacts and parenchymal growth pattern during specification, budding, migration, and lobulation.

Författare och institution:
Henrik Fagman (Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi); Louise Andersson (Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi); Mikael Nilsson (Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi)
Publicerad i:
Developmental dynamics : an official publication of the American Association of Anatomists, 235 ( 2 ) s. 444-55
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Normal mouse thyroid development has been revised to identify critical morphogenetic events. The early thyroid primordium associates with the aortic sac endothelium at the time of specification and budding. The vascular contact is lost after the thyroid buds from the pharyngeal endoderm, but is resumed before the gland divides to form two lobes. Lateral expansion of parenchyma takes place along the course of the third pharyngeal arch arteries. Thyroid precursor cells expressing Titf1/Nkx2.1 do not proliferate until the migration stage, implicating that progenitors likely are recruited from outside the thyroid placode. Early lobulation involves engulfment of the entire ultimobranchial bodies by the growing midline thyroid. At the same time, proliferation of the ultimobranchial body epithelium is silenced preceding the differentiation of C cells. Before folliculogenesis, thyroid lobe enlargement is reminiscent of a budding-branching-like growth pattern. It is suggested that thyroid inductive signals arise from embryonic vessels, and that this provides ideas to conceptually new pathogenetic mechanisms of thyroid dysgenesis.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Animals, Cell Movement, Endoderm, cytology, Mice, Mice, Inbred C57BL, Stem Cells, cytology, Thyroid Gland, cytology, embryology
Postens nummer:
Posten skapad:
2007-11-01 14:14
Posten ändrad:
2011-01-20 09:59

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