transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Suppression of nocturnal fatty acid concentrations by bedtime carbohydrate supplement in type 2 diabetes: effects on insulin sensitivity, lipids, and glycemic control.

Författare och institution:
Mette Axelsen (Institutionen för invärtesmedicin, Avdelningen för internmedicin); Peter Lönnroth (Institutionen för invärtesmedicin, Avdelningen för internmedicin); Ragnhild Arvidsson Lenner (Institutionen för invärtesmedicin, Avdelningen för klinisk näringslära); M R Taskinen (-); Ulf Smith (Institutionen för invärtesmedicin, Avdelningen för internmedicin)
Publicerad i:
The American journal of clinical nutrition, 71 ( 5 ) s. 1108-14
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
BACKGROUND: Bedtime ingestion of slow-release carbohydrates leads to sustained nocturnal fatty acid suppression and improved glucose tolerance in type 2 diabetic patients. OBJECTIVE: This study assessed the effects of 2 different doses of bedtime carbohydrate supplement (BCS) on morning glycemic control and glycated hemoglobin (Hb A(1c)) in type 2 diabetic patients. In addition, the effects of the high-dose BCS on insulin sensitivity and postprandial glucose and triacylglycerol concentrations were assessed. DESIGN: Two BCS doses were studied separately in 7-wk randomized, placebo-controlled, double-blind studies with either a parallel (low-dose BCS; n = 24 patients) or crossover (high-dose BCS; n = 14 patients) design. The effects of the low and high doses (0.30 and 0.55 g uncooked cornstarch/kg body wt, respectively) were compared with those of a starch-free placebo. RESULTS: Compared with the starch-free placebo, the high-dose BCS ( approximately 45 g) produced enhanced nocturnal glucose (P < 0.01) and insulin (P < 0.01) concentrations as well as a 32% suppression of fatty acid concentrations (P < 0.01). Moreover, glucose tolerance (P < 0.05) and C-peptide response (P < 0.05) improved after breakfast the next morning. The low-dose BCS ( approximately 25 g) improved fasting blood glucose concentrations (P < 0.05). However, there were no improvements in insulin sensitivity, postprandial triacylglycerol concentrations, or Hb A(1c) after 7 wk. CONCLUSION: Nocturnal fatty acid suppression by BCS improved fasting and postprandial blood glucose concentrations in type 2 diabetic patients the next morning. In contrast, no improvements in insulin sensitivity, postprandial triacylglycerol concentrations, or long-term glycemic control assessed by Hb A(1c) were seen after BCS supplementation.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Endokrinologi och diabetes ->
Blood Glucose, analysis, Body Weight, C-Peptide, blood, Circadian Rhythm, Cross-Over Studies, Diabetes Mellitus, Type 2, blood, metabolism, Double-Blind Method, Fatty Acids, blood, Female, Glucose Tolerance Test, Hemoglobin A, Glycosylated, analysis, Humans, Insulin, blood, Insulin Resistance, physiology, Lactic Acid, blood, Male, Middle Aged, Starch, administration & dosage, Triglycerides, blood
Postens nummer:
Posten skapad:
2007-11-01 11:45
Posten ändrad:
2010-01-19 17:51

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007