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Göteborgs universitets publikationer

Fat distribution, lipid accumulation in the liver, and exercise capacity do not explain the insulin resistance in healthy males with a family history for type 2 diabetes.

Författare och institution:
Else H Johanson (Institutionen för invärtesmedicin, Avdelningen för internmedicin); Per-Anders Jansson (Institutionen för invärtesmedicin, Avdelningen för internmedicin); Lars Lönn (Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism); Yuji Matsuzawa (-); Tohru Funahashi (-); Marja-Riitta Taskinen (-); Ulf Smith (Institutionen för invärtesmedicin, Avdelningen för internmedicin); Mette Axelsen (Institutionen för invärtesmedicin, Avdelningen för internmedicin)
Publicerad i:
The Journal of clinical endocrinology and metabolism, 88 ( 9 ) s. 4232-8
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
To explore the mechanisms for the insulin resistance associated with a family history of type 2 diabetes, we studied 16 healthy men with at least two first-degree relatives with type 2 diabetes and 16 control subjects without known heredity. They were pair-wise matched for age, body mass index, and fasting triglycerides and underwent an oral glucose tolerance test, iv glucose infusion to measure the early insulin secretion, euglycemic hyperinsulinemic clamp, computed tomography scan, 7-d food record, and a cardiopulmonary exercise test to measure peak oxygen uptake. Insulin sensitivity index was 30% lower (P = 0.02) in relatives, compared with controls, but fasting and 2-h blood glucose and first-phase insulin secretion were similar. There were no differences in mean fasting free fatty acid levels, amount of sc or visceral adipose tissue, or fat accumulation in the liver. Dietary intake and peak oxygen uptake were also similar. However, multiple regression analysis of both groups showed that fat in the liver and physical capacity were, like known heredity for type 2 diabetes, independent predictors of insulin sensitivity. Thus, lipid accumulation in the liver and physical capacity are related to insulin sensitivity, but neither of these factors nor the amount and distribution of the body fat can explain the insulin resistance associated with a family history for type 2 diabetes.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Endokrinologi och diabetes ->
Adiponectin, Adipose Tissue, anatomy & histology, Adult, Anaerobic Threshold, physiology, Anthropometry, Body Composition, physiology, Body Mass Index, Diabetes Mellitus, Type 2, genetics, Diet, Exercise, physiology, Exercise Test, Fatty Acids, Nonesterified, blood, Glucose Clamp Technique, Glucose Tolerance Test, Humans, Insulin, blood, Insulin Resistance, physiology, Intercellular Signaling Peptides and Proteins, Lipid Metabolism, Liver, metabolism, Male, Middle Aged, Phenotype, Proteins, metabolism, Regression Analysis, Triglycerides, blood
Postens nummer:
Posten skapad:
2007-11-01 11:36
Posten ändrad:
2010-01-26 12:43

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