transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Reduced exercise endurance in interleukin-6-deficient mice

Författare och institution:
Jenny Fäldt (Institutionen för invärtesmedicin, Avdelningen för internmedicin); Ingrid Wernstedt (Institutionen för invärtesmedicin, Avdelningen för kroppssammansättning och metabolism); Sharyn Fitzgerald (Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi); Kristina Wallenius (Wallenberglaboratoriet); Göran Bergström (Hjärt-kärlinstitutionen); John-Olov Jansson (Wallenberglaboratoriet)
Publicerad i:
Endocrinology, 145 ( 6 ) s. 2680-6
0013-7227 (Print)
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
IL-6 is produced and released in large amounts from skeletal muscle during prolonged exercise in both mice and humans, but there are few data indicating the biological significance of this. IL-6 exerts metabolic effects such as stimulating energy expenditure and reducing body fat mass. We have now investigated the effects of IL-6 deficiency on exercise endurance and energy expenditure in preobese and obese IL-6-deficient (IL-6(-/-)) mice. Four-month-old preobese and 7-month-old obese IL-6(-/-) male mice backcrossed to C57BL/6 and their littermate controls were exercised on a treadmill, and energy expenditure was measured as oxygen consumption with the use of indirect calorimetry. The preobese IL-6(-/-) mice were significantly leaner than the control mice, whereas the older IL-6(-/-) mice, as expected, had developed obesity. Resting young, but not older, IL-6(-/-) mice had an elevated respiratory exchange ratio (RER), indicating that they oxidize carbohydrates rather than fat for energy utilization. During exercise, the young and older IL-6(-/-) mice had a reduced endurance and a progressive decrease in oxygen consumption compared with control mice. There was no difference in RER in young IL-6(-/-) mice, whereas RER was enhanced in older IL-6(-/-), mice during exercise. In summary, IL-6(-/-) mice have reduced endurance and energy expenditure during exercise, suggesting that IL-6 is necessary for normal exercise capacity.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Animals, Body Composition, Energy Metabolism, Glycogen/blood, Interleukin-6/deficiency/*metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Motor Activity, Obesity/blood/metabolism/*physiopathology, Physical Endurance/*physiology, Pulmonary Gas Exchange
Postens nummer:
Posten skapad:
2007-10-30 14:35
Posten ändrad:
2007-11-01 08:05

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007