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Göteborgs universitets publikationer

The AST/ALT ratio as an indicator of cirrhosis in patients with PBC.

Författare och institution:
Helena Nyblom (Institutionen för medicin, avdelningen för invärtesmedicin); Einar Björnsson (Institutionen för medicin, avdelningen för invärtesmedicin); Magnus Simrén (Institutionen för medicin, avdelningen för invärtesmedicin); Frank Aldenborg (Institutionen för biomedicin, avdelningen för patologi); Sven Almer (-); Rolf Olsson (Institutionen för medicin, avdelningen för invärtesmedicin)
Publicerad i:
Liver international : official journal of the International Association for the Study of the Liver, 26 ( 7 ) s. 840-5
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
OBJECTIVES: A non-invasive, simple and non-expensive test to predict cirrhosis would be highly desirable. The aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio has been proven to be such an indicator of cirrhosis in alcoholic liver disease, hepatitis C. AIM: To test whether the AST/ALT ratio is a marker of cirrhosis also in patients with primary biliary cirrhosis (PBC). METHODS: The study consisted of 160 patients. In 126 patients, we had clinical and laboratory data at the time of diagnosis and follow-up with outcome: liver-related death, liver transplantation and survival. In 121 patients, we had laboratory data and liver histology. RESULTS: We found that the AST/ALT ratio was significantly higher in cirrhotic patients than in non-cirrhotic patients. A high AST/ALT ratio was significantly associated with esophageal varices and ascites. In a multivariate analysis, bilirubin and ALP were predictors of poor prognosis. CONCLUSION: The AST/ALT ratio seems to be of clinical value as a hint to the diagnosis of cirrhosis in patients with PBC but not as a prognostic factor.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Adult, Aged, Alanine Transaminase, blood, Aspartate Aminotransferases, blood, Biological Markers, Case-Control Studies, Disease Progression, Female, Humans, Liver Cirrhosis, blood, etiology, physiopathology, Liver Cirrhosis, Biliary, blood, physiopathology, Liver Function Tests, Male, Middle Aged, Predictive Value of Tests, Prognosis, Sensitivity and Specificity
Postens nummer:
Posten skapad:
2007-10-25 16:14
Posten ändrad:
2011-01-20 10:00

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