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Göteborgs universitets publikationer

[Limited value of prenatal risk group screening for heart abnormalities. Time for a general screening?]

Författare och institution:
Kerstin Åmark (Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik); L. A. Mattsson (-); Jan Sunnegårdh (Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik); Mats Mellander (Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik)
Publicerad i:
Lakartidningen, 101 ( 48 ) s. 3882, 3884-6, 3888-9
0023-7205 (Print)
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
544 fetuses at increased risk of cardiac malformations were examined by echocardiography from gestational week 14 to 40 (median 21), during the period January 1989-March 2002. A heart defect was diagnosed in 70 fetuses. Three false positive diagnoses and eight false negative diagnoses occurred (sensitivity 89 % and specificity 99 %). Seven were terminated (three with trisomy, two with concomitant diaphragmatic hernia and two with single ventricles) and eight died in utero. 22 of 52 liveborn infants died during the neonatal period. Fetal arrhythmia was diagnosed in 30 cases of which eight died prenatally. This risk group screening identified only 3.3 % of all infants with heart defects born during the study period. The ambition to diagnose a greater proportion prenatally would require a general screening program. In order to guarantee a high quality of specialized fetal cardiology service, referrals should be centralized to only a few units in the country.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Arrhythmia/ultrasonography, False Negative Reactions, False Positive Reactions, Female, Heart Defects, Congenital/*ultrasonography, Heart Rate, Fetal/physiology, Humans, Infant, Newborn, *Mass Screening, Neonatal Screening, Pregnancy, Risk Factors, Sensitivity and Specificity, Ultrasonography, Prenatal/*standards/statistics & numerical data
Postens nummer:
Posten skapad:
2007-10-24 13:24
Posten ändrad:
2011-01-20 10:00

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