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Göteborgs universitets publikationer

Potency ratio fluticasone propionate (Flixotide Diskus)/budesonide (Pulmicort Turbuhaler)

Författare och institution:
B. Ställberg (-); E. Pilman (-); Bengt-Eric Skoogh (Institutionen för medicin, avdelningen för invärtesmedicin); B. A. Hermansson (-)
Publicerad i:
Respir Med, 101 ( 3 ) s. 610-5
0954-6111 (Print)
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
In the choice of, or switch between, various inhaled corticosteroids (ICS) it is important to know equipotent doses for clinical treatment effects of the alternatives. Various ICS do have different inherent potency. Further, the ICS are delivered from inhalers that may differ markedly in output characteristics and drug delivery to intrapulmonary airways. Therefore, clinical efficacy comparisons must include drug-inhaler comparisons. We estimated the therapeutic potency ratio of the Flixotide Diskus (fluticasone propionate, FP) and the Pulmicort Turbuhaler (budesonide, BUD) in steroid-naive asthma patients, using a dose-reduction technique (FP 500-0 mcg/day, BUD 800-0 mcg/day). The dose defining end point was loss of asthma control in this paper denoted as exacerbation. In total, 282 patients with proven asthma were enrolled in the study, and 103 in the FP group and 98 in the BUD group completed the study per protocol. In total, 80 patients in the FP-group and 79 in the BUD-group experienced a dose defining exacerbation. The exacerbation frequency increased in a dose-dependent way as the dose was titrated down. From these data the potency difference between the present drug inhaler combinations, Flixotide Diskus and Pulmicort Turbuhaler, was calculated to be between 1.50:1 (95% CI 1.10:1-2.05:1) and 1.75:1 (CI 1.26:1-2.43:1) depending on if patients with insufficient steroid-response were excluded from the calculations or not. In these steroid-naive patients, the potency difference was evident only at low daily doses, below 200 mcg.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Lungmedicin och allergi
Administration, Inhalation, Adult, Androstadienes/*administration & dosage/adverse effects, Asthma/*drug therapy/physiopathology, Bronchodilator Agents/*administration & dosage/adverse effects, Budesonide/*administration & dosage/adverse effects, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Glucocorticoids/*administration & dosage/adverse effects, Humans, Male, Metered Dose Inhalers, Peak Expiratory Flow Rate/physiology, Treatment Outcome
Postens nummer:
Posten skapad:
2007-10-24 13:17

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