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Göteborgs universitets publikationer

Antimicrobial susceptibility of invasive pneumococcal isolates from a region in south-west Sweden 1998-2001.

Författare och institution:
Erik Backhaus (-); Stefan Berg (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa); Birger Trollfors (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa); Rune Andersson (-); Elisabet Persson (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa); Berndt E B Claesson (-); Peter Larsson (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Elisabeth Ek (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Lars Jonsson (-); Gunilla Rådberg (-); Siv Johansson (-); Torvald Ripa (-); Diana Karlsson (-); Kerstin Andersson (-)
Publicerad i:
Scandinavian journal of infectious diseases, 39 ( 1 ) s. 19-27
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Invasive disease caused by antibiotic resistant pneumococci is a worldwide problem. All invasive pneumococcal strains in an area of south-west Sweden with 1.7 million inhabitants were collected prospectively during 1998-2001. Minimum inhibitory concentrations (MICs) were determined by E-test and correlated to serotypes and clinical characteristics. Of 827 strains, 744 (90%) were susceptible (S) to all agents tested and 83 (10%) were indeterminate (I) or resistant (R) to at least 1 agent. 22 isolates (2.7%) were I to penicillin (MIC >0.06 to < or = 1.0 mg/l), but none were R (MIC >1.0 mg/l). Numbers and proportions of decreased susceptibility against other agents tested were as follows: erythromycin R: 30 (3.6%), clindamycin R: 6 (0.7%), tetracycline R: 16 (1.9%), moxifloxacin R: 1 (0.1%), cotrimoxazole I: 17 (2%) and R: 31(4%). Non-susceptibility to at least 1 agent was not correlated with age, clinical manifestation, underlying diseases and outcome. The serotype distribution differed between non-susceptible and susceptible strains. The serotypes in the 7-valent pneumococcal conjugate vaccine covered 42% of all infections and 73% of those caused by non-susceptible strains. In conclusion, the impact of antibiotic resistance in invasive pneumococcal disease remains limited in south-west Sweden.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Drug Resistance, Bacterial, Female, Humans, Infant, Infant, Newborn, Male, Microbial Sensitivity Tests, statistics & numerical data, Middle Aged, Penicillins, pharmacology, Pneumococcal Infections, drug therapy, epidemiology, Streptococcus pneumoniae, drug effects, pathogenicity, Sweden, epidemiology
Postens nummer:
Posten skapad:
2007-10-22 16:27
Posten ändrad:
2011-01-20 09:58

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