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Göteborgs universitets publikationer

Neurokinin 1 receptor signaling affects the local innate immune defense against genital herpes virus infection.

Författare och institution:
Alexandra Svensson (Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning); Joanna Kaim (Institutionen för medicinsk mikrobiologi och immunologi); Carina Mallard (Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi); Annika Olsson (-); Ernst Brodin (-); Tomas Hökfelt (-); Kristina Eriksson (Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning)
Publicerad i:
Journal of immunology (Baltimore, Md. : 1950), 175 ( 10 ) s. 6802-11
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
We show that genital infection with neurotropic HSV type 2 (HSV-2) induced a significant increase of the neuropeptide substance P (SP) within the genital tract of mice. SP was shown to weakly interfere with the HSV-2 replication. Furthermore, lack of SP signaling through the use of mice deficient in the SP receptor, neurokinin 1 receptor (NK1R), revealed an important role for SP in the innate defense against HSV-2. NK1R-deficient mice had significantly enhanced levels of HSV-2 in the genital tract and in the CNS following infection and a significantly accelerated disease progression, which was associated with an impaired NK cell activity locally in the vagina. Lack of NK1R signaling did, however, not impair the animals' ability to mount a protective immune response to HSV-2 following vaccination with an attenuated virus. Both NK1R+/+ and NK1R-/- mice developed strong HSV-2-specific Th1 T cell responses following vaccination. No genital viral replication was observed in either vaccinated NK1R-deficient or NK1R+/+ control animals following a genital HSV-2 challenge, and all of these animals survived without any symptoms of disease. In conclusion, the present results indicate that SP and NK1R signaling contributes to the innate resistance against HSV-2 infection in mice.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Mikrobiologi inom det medicinska området
Animals, Central Nervous System, pathology, virology, Female, Herpes Genitalis, immunology, metabolism, prevention & control, virology, Herpes Simplex Virus Vaccines, pharmacology, Herpesvirus 2, Human, drug effects, immunology, physiology, Immunity, Natural, Killer Cells, Natural, immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptors, Neurokinin-1, deficiency, genetics, immunology, Signal Transduction, Substance P, metabolism, pharmacology, Vaccines, Attenuated, pharmacology, Vagina, immunology, metabolism, virology, Virus Replication, drug effects
Postens nummer:
Posten skapad:
2007-10-22 11:28
Posten ändrad:
2011-01-20 10:00

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