transparent gif


Ej inloggad.

Göteborgs universitets publikationer

A behavioural pattern analysis of hypoglutamatergic mice-effects of four different antipsychotic agents

Författare och institution:
Marie Nilsson (Institutionen för fysiologi och farmakologi); S. Waters (-); Nicholas Waters (-); A. Carlsson (-); Maria L. Carlsson (Institutionen för klinisk neurovetenskap)
Publicerad i:
J Neural Transm, 108 ( 10 ) s. 1181-96
0300-9564 (Print)
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
In a hypoglutamatergic rodent model, we have observed certain behaviours that might have relevance for the cognitive impairments seen in autism and schizophrenia. Thus, hypoglutamatergic mice show defective habituation, impaired attention, a meagre behavioural repertoire and a general behavioural primitivization. The aim of the present study was to characterise and quantify changes in movement pattern in mice rendered hypoglutamatergic by means of MK-801 treatment, using an automated video tracking system. Further, the effects of four different antipsychotic drugs, the classical neuroleptic haloperidol, the atypical antipsychotic clozapine, the DA D2/5-HT2A antagonist risperidone and the selective 5-HT2A-receptor antagonist M100907, were compared with respect to effects on NMDA antagonist-induced movement pattern alterations. We found that each receptor antagonist had a unique effect on the MK-801-induced behavioural primitivization. Haloperidol was unable to affect the monotonous behaviour induced by MK-801, while risperidone, clozapine and M100907 produced movement patterns of high intricacy.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Farmakologi och toxikologi ->
Animals, Antipsychotic Agents/*pharmacology, Behavior, Animal/*drug effects/*physiology, Clozapine/pharmacology, Dizocilpine Maleate/pharmacology, Dopamine Antagonists/pharmacology, Drug Combinations, Excitatory Amino Acid Antagonists/*pharmacology, Fluorobenzenes/pharmacology, Glutamic Acid/*deficiency, Haloperidol/pharmacology, Injections, Intraperitoneal, Male, Mice, Motor Activity/drug effects/physiology, Piperidines/pharmacology, Risperidone/pharmacology, Serotonin Antagonists/pharmacology
Postens nummer:
Posten skapad:
2007-10-19 15:51

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007