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Göteborgs universitets publikationer

Investigation of transcription factor AP-2 beta genotype in women with premenstrual dysphoric disorder.

Författare och institution:
Mattias Damberg (-); Lars Westberg (Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi); Cecilia Berggård (-); Mikael Landén (Institutionen för klinisk neurovetenskap, Sektionen för psykiatri); Charlotta Sundblad-Elverfors (Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi); Olle Eriksson (-); Tord Naessén (-); Agneta Ekman (Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi); Elias Eriksson (Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi)
Publicerad i:
Neuroscience letters, 377 ( 1 ) s. 49-52
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
It has repeatedly been shown that the serotonergic system is involved in the symptomatology of premenstrual dysphoric disorder (PMDD). Women with PMDD are reported to differ from symptom-free controls with regard to serotonin-related biological markers. Evidence from family and twin studies suggests a genetic contribution to the aetiology of PMDD. The expression of human transcription factor AP-2beta in neural crest cell lineages and neuroectodermal cells suggests that this protein may be of importance for functional characteristics of neurons by regulating the expression of target genes. Within the monoaminergic systems, several genes have binding sites for AP-2beta in regulatory regions, suggesting an involvement of AP-2beta in these systems. The gene encoding AP-2beta is located on chromosome 6p12-p21.1 and includes a polymorphic region consisting of a variable number of [CAAA] repeats located in the second intron. We have earlier shown that AP-2beta genotype is associated with serotonergic phenotypes and that brainstem levels of AP-2beta correlate positively to serotonin metabolism in rat frontal cortex. The aim of this study was to investigate the relationship between PMDD and transcription factor AP-2beta genotype. The participants included 176 women with PMDD and 91 healthy controls. Genotyping was performed by polymerase chain reactions. We did not observe any differences in AP-2beta genotype frequencies between PMDD subjects and controls. Our results suggest that AP-2beta genotype is not a risk factor for PMDD. To our knowledge, this is the first study investigating transcription factor AP-2beta genotype in women with PMDD. Hence, these results should be considered preliminary until replicated.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Adolescent, Adult, DNA-Binding Proteins, genetics, Depressive Disorder, genetics, psychology, Female, Genotype, Humans, Middle Aged, Premenstrual Syndrome, genetics, psychology, Transcription Factor AP-2, Transcription Factors, genetics
Postens nummer:
Posten skapad:
2007-10-19 12:53
Posten ändrad:
2014-04-10 10:27

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