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Göteborgs universitets publikationer

The CD16-/CD56bright subset of NK cells is resistant to oxidant-induced cell death

Författare och institution:
Fredrik B Thorén (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Ana Romero (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Svante Hermodsson (Institutionen för biomedicin, avdelningen för infektionssjukdomar); Kristoffer Hellstrand (Institutionen för biomedicin, avdelningen för infektionssjukdomar)
Publicerad i:
J Immunol, 179 ( 2 ) s. 781-5
0022-1767 (Print)
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Phagocyte-derived reactive oxygen species ("oxygen radicals") have been ascribed a suppressive role in immunoregulation by inducing dysfunction and apoptotic cell death in lymphocytes. Earlier studies show that human NK cells are exceptionally sensitive to oxygen radical-induced apoptosis and functional inhibition. Two subsets of human CD56(+) NK cells have been identified: the highly cytotoxic CD56(dim) cells which constitute >90% of NK cells in peripheral blood, and the less cytotoxic but efficiently cytokine-producing CD56(bright) cells. In this study, we demonstrate that the CD56(bright) subset of NK cells, in contrast to CD56(dim) cells, remains viable and functionally intact after exposure to phagocyte-derived or exogenously added oxygen radicals. The resistance of CD56(bright) cells to oxidative stress was accompanied by a high capacity of neutralizing exogenous hydrogen peroxide, and by a high cell-surface expression of antioxidative thiols. Our results imply that CD56(bright) NK cells are endowed with an efficient antioxidative defense system that protects them from oxygen radical-induced inactivation.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Postens nummer:
Posten skapad:
2007-10-18 12:54
Posten ändrad:
2011-01-20 09:59

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