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Göteborgs universitets publikationer

The renin-angiotensin system in kidney development

Författare och institution:
Yun Chen (Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi); Daina Lasaitiene (Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi); Peter Friberg (Hjärt-kärlinstitutionen)
Publicerad i:
Acta Physiol Scand, 181 ( 4 ) s. 529-35
0001-6772 (Print)
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
All components of the renin-angiotensin system (RAS) are highly expressed in the developing kidney in a pattern suggesting a role for angiotensin II in renal development. In support of this notion, pharmacological interruption of angiotensin II type-1 (AT(1)) receptor signalling in animals with an ongoing nephrogenesis produces specific renal abnormalities characterized by papillary atrophy, abnormal wall thickening of intrarenal arterioles, tubular atrophy associated with expansion of the interstitium, and a marked impairment in urinary concentrating ability. Similar changes in renal morphology and function develop also in mice with targeted inactivation of genes encoding renin, angiotensinogen, angiotensin-converting enzyme, or both AT(1) receptor isoforms simultaneously. Taken together, these results clearly indicate that an intact signalling through AT(1) receptors is a prerequisite for normal renal development. The present report mainly reviews the renal abnormalities induced by blocking the RAS pharmacologically in experimental animal models. In addition, pathogenetic mechanisms are discussed.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Animals, Disease Models, Animal, Embryonic and Fetal Development/physiology, Kidney/abnormalities/*embryology/physiopathology, Mice, Rats, Receptor, Angiotensin, Type 1/physiology, Renin-Angiotensin System/drug effects/*physiology
Postens nummer:
Posten skapad:
2007-10-18 12:52
Posten ändrad:
2011-01-20 09:59

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