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Periodontal wound healing following GTR therapy of dehiscence-type defects in the monkey: short-, medium- and long-term healing.

Författare och institution:
Filippo Graziani (-); Lars Laurell (Odontologiska institutionen, Avdelningen för parodontologi); Maurizio Tonetti (-); Jan Gottlow (Institutionen för de kirurgiska disciplinerna, Avdelningen för biomaterialvetenskap); Tord Berglundh (Odontologiska institutionen, Avdelningen för parodontologi)
Publicerad i:
Journal of clinical periodontology, 32 ( 8 ) s. 905-14
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
OBJECTIVE: To describe periodontal wound healing in dehiscence-type defects following guided tissue re-generation (GTR) therapy. METHODS: Ten adult Macaca fascicularis monkeys were used. Buccal dehiscence-type defects were created at the maxillary second pre-molars and second molars. After 3 months, GTR surgery was performed. The animals were euthanized at 6 weeks, 6 months and 2 years after surgery. Block biopsies were harvested, and prepared for histological analysis. RESULTS: A new attachment apparatus was structured already after 6 weeks of healing. A 10-20 microm thin layer of acellular extrinsic fibre cementum (AEFC) had formed along the instrumented root surface. At 6 months, the thickness of the supracrestal cementum was comparable with that at 6 weeks, while the thickness of the subcrestal cementum had increased to 40-60 microm. In this zone, the cementum consisted of an inner layer of AEFC attached to the circum-pulpal dentin and an outer layer of cellular mixed fibre cementum (CMFC). The numerical extrinsic fibre density was twice that at 6 weeks. At 2 years, the periodontal tissues resembled the pristine periodontium. CONCLUSION: Periodontal healing following GTR therapy of recession-type defects will result in a restitutio ad integrum, i.e. healing by re-generation. A continuous maturation process occurs over at least 2 years.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Absorbable Implants, Alveolar Bone Loss, surgery, Animals, Bone Regeneration, Cementogenesis, Citrates, Dental Cementum, physiology, Guided Tissue Regeneration, Periodontal, methods, Macaca fascicularis, Membranes, Artificial, Periodontal Ligament, physiology, Polyesters, Polytetrafluoroethylene, Regeneration, physiology, Wound Healing, physiology
Postens nummer:
Posten skapad:
2007-10-17 14:04
Posten ändrad:
2008-01-10 10:33

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