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Göteborgs universitets publikationer

SweDCIS: Radiotherapy after sector resection for ductal carcinoma in situ of the breast. Results of a randomised trial in a population offered mammography screening.

Författare och institution:
Stefan O Emdin (-); Bengt Granstrand (-); Anita Ringberg (-); Kerstin Sandelin (-); Lars-Gunnar Arnesson (-); Hans Nordgren (-); Harald Anderson (-); Hans Garmo (-); Lars Holmberg (-); Arne Wallgren (Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi); The Swedish Breast Cancer Group (-)
Publicerad i:
Acta oncologica (Stockholm, Sweden), 45 ( 5 ) s. 536-43
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
We studied the effect of postoperative radiotherapy (RT) after breast sector resection for ductal carcinoma in situ (DCIS). The study protocol stipulated radical surgery but microscopically clear margins were not mandatory. We randomised 1,046 operated women to postoperative RT or control between 1987 and 1999. The primary endpoint was ipsilateral local recurrence. Secondary endpoints were contralateral breast cancer, distant metastasis and death. After a median follow-up of 5.2 years (range 0.1-13.8) there were 44 recurrences in the RT group corresponding to a cumulative incidence of 0.07 (95% confidence interval (CI) 0.05-0.10). In the control group there were 117 recurrences giving a cumulative incidence of 0.22 (95% CI 0.18-0.26) giving an overall hazard ratio of 0.33 (95% CI 0.24-0.47, p < 0.0001). Twenty two percent of the patients had microscopically unknown or involved margins. We found no evidence for different effects of RT on the relative risk of invasive or in situ recurrence. Secondary endpoints did not differ. Women undergoing sector resection for DCIS under conditions of population based screening mammography benefit from postoperative RT to the breast. Seven patients needed RT-treatment to prevent one recurrence.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Cancer och onkologi
Breast Neoplasms, diagnosis, radiotherapy, surgery, Carcinoma in Situ, diagnosis, radiotherapy, surgery, Disease-Free Survival, Female, Follow-Up Studies, Humans, Mammography, methods, Mass Screening, methods, Middle Aged, Predictive Value of Tests, Radiotherapy, Adjuvant, Recurrence, Sensitivity and Specificity, Survival Analysis, Sweden, Treatment Outcome
Postens nummer:
Posten skapad:
2007-10-16 13:01
Posten ändrad:
2011-01-20 10:00

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