transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Modulation of responses of four types of feline ascending tract neurons by serotonin and noradrenaline.

Författare och institution:
Elzbieta Jankowska (Institutionen för fysiologi och farmakologi); Ingela Hammar (Institutionen för fysiologi och farmakologi); L Djouhri (Institutionen för fysiologi och farmakologi); C Hedén (Institutionen för fysiologi och farmakologi); Z Szabo-Läckberg (Institutionen för fysiologi och farmakologi); X K Yin (Institutionen för fysiologi och farmakologi)
Publicerad i:
The European journal of neuroscience, 9 ( 7 ) s. 1375-87
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Modulation of responses of four types of ascending tract cells by noradrenaline and serotonin was compared in order to investigate how information forwarded by these cells may be gated by monoaminergic tract neurons. Spinocervical tract, postsynaptic dorsal column and dorsal spinocerebellar tract neurons located in Clarke's column and in the dorsal horn were identified by their axonal projections. Noradrenaline and serotonin were applied ionophoretically close to a selected neuron, and their effects were tested on extracellularly recorded responses of this neuron to electrical stimulation of low-threshold skin afferents and group II muscle spindle afferents. The modulatory actions of noradrenaline and serotonin were estimated from changes in the number of responses evoked by 30 successive stimuli, the minimal latencies of these responses, and their firing frequency. All four populations of ascending tract neurons investigated were modulated by serotonin and noradrenaline, but not in the same way. The responses were most often depressed by noradrenaline and facilitated by serotonin, but in some types of neuron they were affected in the same direction. Transmission from low-threshold skin and group II muscle afferents changed in the same direction in some types of neuron but in the opposite direction in other types. The results indicate that transfer of information from skin and group II muscle afferents to supraspinal centres may be gated by descending monoaminergic pathways in a highly differentiated manner, and is adjusted to the requirements of various behavioural situations.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Medicinska grundvetenskaper ->
Fysiologi ->
Animals, Cats, Cerebellum, cytology, physiology, Neck, Neurons, Afferent, drug effects, physiology, Norepinephrine, pharmacology, Serotonin, pharmacology, Spinal Cord, cytology, drug effects, physiology, Synapses, physiology
Postens nummer:
Posten skapad:
2007-10-15 13:53
Posten ändrad:
2011-01-20 09:59

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007