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Göteborgs universitets publikationer

The reciprocal association of adipocytokines with insulin resistance and C-reactive protein in clinically healthy men

Författare och institution:
Carl Johan Behre (Wallenberglaboratoriet); Björn Fagerberg (Institutionen för invärtesmedicin, Avdelningen för internmedicin & Wallenberglaboratoriet); Lillemor Mattsson Hultén (Wallenberglaboratoriet); Johannes Hulthe (Wallenberglaboratoriet)
Publicerad i:
Metabolism, 54 ( 4 ) s. 439-44
0026-0495 (Print)
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
In experimental models, adiponectin improves and tumor necrosis factor alpha (TNF- alpha ) impairs insulin action, and the expression of these adipocytokines seems to have a reciprocal regulation. The aim was to examine whether in a cross-sectional study, associations supporting this concept may be found in 58-year-old clinically healthy men, and also the relation to C-reactive protein (CRP). In 102 men, euglycemic hyperinsulinemic clamp was used to assess glucose infusion rate (GIR). Total body fat (dual-energy x-ray absorptiometry), plasma adiponectin (radioimmunoassay), TNF-alpha , and CRP (enzyme-linked immunosorbent assay) were measured. Adiponectin correlated positively to GIR (r=0.33, P<.001) and negatively to total fat mass (r=-0.29, P=.004), whereas TNF- alpha showed reverse associations (r=-0.31, P<.01, and r=0.31, P<.01). Adiponectin and TNF- alpha were negatively correlated (-0.28, P=.006). An interaction term (TNF- alpha /adiponectin ratio) and body fat together explained 31.3% (P<.001) in GIR variability. The odds ratio for having insulin resistance was 9.3 (95% CI, 2.2-38.9) in subjects with TNF-alpha values above and adiponectin levels below the median, as compared to subjects with TNF- alpha values below and adiponectin levels above the median. Total fat and TNF-alpha , but not adiponectin, were significantly associated with log CRP (R2=20%, P<.001). In conclusion, this study in man showed that plasma adiponectin and TNF-alpha were independently and reversely associated with insulin resistance. C-reactive protein levels were related to TNF-alpha and obesity.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Adiponectin, Adipose Tissue, Body Composition, C-Reactive Protein/*analysis, Cross-Sectional Studies, Densitometry, X-Ray, Glucose Clamp Technique, Humans, Insulin Resistance/*physiology, Intercellular Signaling Peptides and Proteins/*blood, Male, Middle Aged, Obesity/blood, Odds Ratio, Tumor Necrosis Factor-alpha/*analysis
Postens nummer:
Posten skapad:
2007-09-25 13:57
Posten ändrad:
2011-01-20 09:59

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