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Göteborgs universitets publikationer

Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation

Författare och institution:
Svetlana Sergejeva (Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi); Stefan Ivanov (Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi); Jan Lötvall (Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi); Anders Lindén (Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi)
Publicerad i:
American journal of respiratory cell and molecular biology, 33 ( 3 ) s. 248-53
1044-1549 (Print)
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Recent data indicate that the proinflammatory cytokine, interleukin (IL)-17, stimulates certain effector functions of human macrophages. We evaluated whether IL-17 mediates allergen-induced accumulation of airway macrophages and, if so, whether such an effect relates to the control of macrophage recruitment and survival. BALB/c mice were sensitized and challenged with ovalbumin. Three hours before challenge an anti-mouse IL-17 mAb (a-IL-17) was administered. Sampling was conducted 24 h after the allergen challenge. In vitro chemotaxis assay for blood monocytes and culture of airway macrophages, immunocytochemistry for Fas-antigen, and matrix metalloproteinase-9 (MMP-9) were used to determine the effect of IL-17 on the recruitment, survival, and activity of airway macrophages. A-IL-17 reduced the number of airway neutrophils and macrophages after allergen challenge. In vitro, recombinant IL-17 induced migration of blood monocytes and prolonged survival of airway macrophages. A-IL-17 also increased the expression of Fas-antigen in airway macrophages in vivo. Finally, the expression of MMP-9 by airway neutrophils and macrophages in vivo was downregulated by a-IL-17. This study indicates that endogenous IL-17 mediates the accumulation of macrophages during allergen-induced airway inflammation. IL-17 exerts its effects by acting directly on airway macrophages by promoting their recruitment and survival. Furthermore, IL-17 is involved in controlling the proteolytic activity of macrophages and neutrophils in allergen-induced airway inflammation.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Dermatologi och venereologi
Animals, Apoptosis/immunology, Asthma/immunology, Bronchoalveolar Lavage Fluid/cytology/immunology, Cell Survival/immunology, Cells, Cultured, Chemotaxis, Leukocyte/immunology, Interleukin-17/*immunology/metabolism, Macrophages, Alveolar/*cytology/*immunology/metabolism, Matrix Metalloproteinase 9/metabolism, Mice, Mice, Inbred BALB C, Neutrophils/immunology/metabolism, Pneumonia/*immunology
Postens nummer:
Posten skapad:
2007-09-25 11:10
Posten ändrad:
2011-01-20 09:59

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