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Göteborgs universitets publikationer

Effects of intrauterine inflammation on the developing mouse brain

Författare och institution:
Xiaoyang Wang (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Henrik Hagberg (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa); Changlian Zhu (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi); Bo Jacobsson (Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa); Carina Mallard (Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi)
Publicerad i:
Brain Res, 1144 s. 180-5
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Clinical and experimental evidence indicate that the presence of intrauterine inflammation in pregnancy is not only a cause of preterm birth but is also associated with perinatal brain damage and long-term neurological handicap. In the present study, the neuropathological outcome was investigated in surviving pups in a model of inflammation-induced preterm delivery. C57BL/6 mice were subjected to intrauterine injection of lipopolysaccharide (LPS) or saline, at a time corresponding to 79% of average gestation (gestational day 15). Fetuses that survived after LPS administration were sacrificed on postnatal day 14 (PND 14). At PND 14, the brain weight of LPS-exposed pups was significantly lower than that of saline-exposed. A high proportion of LPS-exposed brains were found affected and exhibited hypomyelination, enlarged ventricles, and in some cortical gray matter lesions were evident. None of these pathologies were detected in sham-treated animals. Conclusions: Intrauterine inflammation impaired brain development and various brain lesions were produced in both the white and gray matter after intrauterine LPS administration in mice.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Animals, Animals, Newborn, Body Weight/drug effects/physiology, Brain/*growth & development/*pathology, Female, Inflammation/mortality/*pathology/*physiopathology, *Lipopolysaccharides, Mice, Mice, Inbred C57BL, Myelin Basic Proteins/metabolism, Organ Size/drug effects/physiology, Pregnancy, *Prenatal Exposure Delayed Effects/chemically, induced/pathology/physiopathology
Postens nummer:
Posten skapad:
2007-09-20 13:33
Posten ändrad:
2011-01-20 10:00

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