transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Can famotidine and omeprazole be combined on a once-daily basis?

Författare och institution:
Lars Fändriks (Institutionen för kliniska vetenskaper, sektionen för kirurgi och kirurgisk gastroforskning); Hans Lönroth (Institutionen för kliniska vetenskaper, sektionen för kirurgi och kirurgisk gastroforskning); A. Pettersson (-); N. Vakil (-)
Publicerad i:
Scandinavian journal of gastroenterology, 42 ( 6 ) s. 689-94
0036-5521 (Print)
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
OBJECTIVE: Prompt and long-standing acid control following once-daily administration of antisecretory drugs is desirable. The objective of this study was to determine whether co-administration of a well-characterized H2-receptor antagonist, famotidine, can be combined with the proton-pump inhibitor omeprazole. MATERIAL AND METHODS: Intragastric 24-h pH-metry was performed in healthy, Helicobacter pylori-negative volunteers on day 1 and after 8 days of daily administration of 20 mg omeprazole, 10 mg famotidine, or a combination of these in a three-way crossover design. RESULTS: A combination of famotidine and omeprazole raised the gastric pH level to >4 in less than 1 h. The percentage of daytime with pH > 4 on day 1 was significantly higher with the combination of omeprazole and famotidine (median: 37%) than that with omeprazole alone (22%; p < 0.05). On day 8, daytime intragastric pH > 4 following treatment with omeprazole (median: 55%) or a combination of omeprazole and famotidine (61%) was superior (p < 0.05) to that with famotidine (21%). On day 1 treatment with both famotidine and the combination (famotidine and omeprazole) showed a significantly shorter time to reach a pH of 4 (medians: 93 and 63 min, respectively) compared with treatment with omeprazole alone (173 min; p < 0.05). CONCLUSIONS: Compared with treatment with omeprazole alone, on day 1 famotidine and omeprazole in combination improved the duration of and time to reach intragastric pH > 4. With regard to duration with pH > 4, the combination therapy was superior to famotidine alone on day 8. The rapid acid control with an H2-receptor antagonist may be combined with the long-lasting antisecretory effect of a proton-pump inhibitor.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Adult, Cross-Over Studies, Drug Administration Schedule, Drug Therapy, Combination, Famotidine/*administration & dosage, Humans, Omeprazole/*administration & dosage
Postens nummer:
Posten skapad:
2007-09-14 15:08
Posten ändrad:
2011-01-20 09:59

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007