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Göteborgs universitets publikationer

CD25-expressing B-lymphocytes in rheumatic diseases

Författare och institution:
Sylvie Amu (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); K. Stromberg (-); Maria Bokarewa (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Andrej Tarkowski (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); Mikael Brisslert (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning)
Publicerad i:
Scand J Immunol, 65 ( 2 ) s. 182-91
0300-9475 (Print)
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
B cells play an important role in the development of autoimmune diseases due to their production of autoantibodies, antigen-presenting capacity and production of pro-inflammatory cytokines. The purpose of the present study was to analyse B cells from rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients, with respect to their expression of the IL-2 receptor (IL-2R) subunit CD25. Using flow cytometry, we found that CD25(+) B cells from RA patients expressed significantly higher frequencies of CD122 and CD132 than CD25(+) B cells from control subjects, indicating a fully functional IL-2R. These CD25(+) B cells also expressed higher frequencies of the co-stimulatory molecule CD80, whereas IgM and IgA expression was decreased compared with CD25(+) B cells from healthy controls. In addition B cells from SLE patients co-expressed CD25 together with CD80, CD122, and CD132, but to a lower degree IgD and IgM, when compared with healthy controls. Taken together, our results indicate that CD25(+) B cells from RA and SLE patients are in a highly activated state, display a more mature phenotype and suggest that this B cell subset may be involved in the pathogenesis of RA and SLE.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Adult, Aged, Arthritis, Rheumatoid/*immunology, B-Lymphocytes/*immunology, Female, Humans, Immunoglobulin A/immunology, Immunoglobulin M/immunology, Interleukin Receptor Common gamma Subunit/analysis, Interleukin-2 Receptor alpha Subunit/*analysis, Interleukin-2 Receptor beta Subunit/analysis, Lupus Erythematosus, Systemic/*immunology, Lymphocyte Activation, Male, Middle Aged, Phenotype
Postens nummer:
Posten skapad:
2007-08-20 15:55
Posten ändrad:
2011-01-20 10:00

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