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Göteborgs universitets publikationer

Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset of inflammatory response and development of overt rheumatoid arthritis

Författare och institution:
S. Rantapaa-Dahlqvist (-); K. Boman (-); Andrej Tarkowski (Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning); G. Hallmans (-)
Publicerad i:
Ann Rheum Dis, 66 ( 1 ) s. 121-3
0003-4967 (Print)
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
OBJECTIVE: To analyse the inflammatory mediators, including monocyte chemoattractant protein-1 (MCP-1), in blood samples donated years before onset of rheumatoid arthritis. Previously, it has been shown in these individuals that antibodies against cyclic citrullinated peptide (anti-CCP) detectable years before the onset of symptoms have a high predictive value for development of rheumatoid arthritis. METHODS: A nested case-control study was performed: patients with rheumatoid arthritis were identified from among blood donors antedating onset by a median of three years (pre-patients, n = 92); four matched controls were selected randomly for each pre-patient. Plasma were analysed for secretory phospholipase A2 (sPLA2) and MCP-1 using ELISA, for high-sensitivity C reactive protein (hsCRP) using the chemiluminescence method and for interleukin-6 using a sensitive bioassay. RESULTS: When the results were stratified for the presence of anti-CCP antibodies and immunoglobulin M-rheumatoid factor (IgM-RF), only MCP-1 levels were found to be significantly raised in patients with anti-CCP and IgM-RF compared with controls. CONCLUSION: Levels of MCP-1 were significantly increased in the plasma of patients having anti-CCP antibodies or IgM-RF and who later developed rheumatoid arthritis. These findings indicate up regulation of chemotactic activity for leucocytes before the development of rheumatoid arthritis.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Adult, Aged, Arthritis, Rheumatoid/*blood, Autoantibodies/*blood, Biological Markers/blood, Blood Donors, C-Reactive Protein/analysis, Case-Control Studies, Chemokine CCL2/*blood, Chi-Square Distribution, Citrulline/*immunology, Disease Progression, Female, Humans, Immunoglobulin M/blood, Male, Middle Aged, Rheumatoid Factor/blood, Severity of Illness Index, Time Factors, *Up-Regulation
Postens nummer:
Posten skapad:
2007-08-20 14:28
Posten ändrad:
2011-01-20 10:00

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