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Göteborgs universitets publikationer

Inhibition of septic arthritis by local administration of taurine chloramine, a product of activated neutrophils

Författare och institution:
Margareta Verdrengh (Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning); Andrej Tarkowski (Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning)
Publicerad i:
J Rheumatol, 32 ( 8 ) s. 1513-7
0315-162X (Print)
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
OBJECTIVE: Taurine is an amino acid able to react with hypochlorous acid, produced endogenously by neutrophils, resulting in the more stable and less toxic taurine chloramine (Tau-Cl). Since Tau-Cl has been shown to down-regulate the production of proinflammatory mediators and to exert anti-bacterial properties, we investigated the efficacy of Tau-Cl treatment for infectious arthritis. METHODS: The murine model of hematogenous septic arthritis involved intravenous injection of a single dose of Staphylococcus aureus. Tau-Cl was administered by daily intraperitoneal injections. In another experiment S. aureus and Tau-Cl were injected intra-articularly. Evaluation of arthritis was performed clinically and histologically. The effect of Tau-Cl on bacterial growth in vitro was also assessed. RESULTS: Growth of staphylococci, including the methicillin-resistant strain 67-0, was inhibited by Tau-Cl. Mice injected with bacteria and Tau-Cl locally in the joint exhibited significantly fewer arthritic lesions. In contrast, there were no obvious differences between Tau-Cl-treated animals and controls with regard to clinical or histological signs of arthritis when bacteria and Tau-Cl were administered systemically. CONCLUSION: Our results show that Tau-Cl exerts an inhibitory effect on the development of bone and cartilage damage in the infected joint when administered intra-articularly.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Animals, Arthritis, Infectious/*drug therapy/*immunology/microbiology, Cells, Cultured, Disease Models, Animal, Down-Regulation/drug effects/immunology, Female, Inflammation Mediators/*pharmacology, Injections, Intra-Articular, Interleukin-6/metabolism, Lymphocytes/cytology/metabolism, Methicillin Resistance, Mice, Mice, Inbred Strains, Neutrophils/*immunology, Spleen/cytology/metabolism, Staphylococcal Infections/drug therapy/immunology, Staphylococcus aureus/drug effects/growth & development, Taurine/*analogs & derivatives/pharmacology
Postens nummer:
Posten skapad:
2007-07-02 14:22
Posten ändrad:
2011-01-20 10:00

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