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Göteborgs universitets publikationer

Role of fibrinogen-binding adhesin expression in septic arthritis and septicemia caused by Streptococcus agalactiae

Författare och institution:
Ing-Marie Jonsson (Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning); G. Pietrocola (-); P. Speziale (-); Margareta Verdrengh (Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning); Andrej Tarkowski (Institutionen för invärtesmedicin, Avdelningen för reumatologi och inflammationsforskning)
Publicerad i:
J Infect Dis, 192 ( 8 ) s. 1456-64
0022-1899 (Print)
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
BACKGROUND: Streptococcus agalactiae (group B streptococcus) is an important human pathogen that causes neonatal pneumonia, sepsis, septic arthritis, and meningitis, as well as severe infections in immunocompromised adult patients. The streptococci produce several molecules important for virulence. METHODS: We used a murine model of sepsis and septic arthritis to assess the role of FbsA, a fibrinogen-binding adhesin of S. agalactiae as a virulence determinant. NMRI mice were inoculated intravenously with S. agalactiae strains isogenic for the expression of FbsA. RESULTS: Inoculation with wild-type (wt) streptococci resulted in significantly higher mortality, more-pronounced weight decrease, and more-severe arthritis, compared with inoculation with the FbsA mutant isogenic strain. Neither active nor passive immunization with FbsA or FbsA-specific antibodies, respectively, resulted in any protection against subsequent infection with the S. agalactiae wt strain. CONCLUSION: Our results clearly indicate that the expression of FbsA by Streptococcus agalactiae is a significant virulence determinant in septic arthritis and septicemia. However, because blocking of the fibrinogen binding properties did not protect the host against the action of FbsA-expressing streptococci, we believe that the FbsA molecule has some other presently unknown biological in vivo properties.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Animals, Arthritis, Infectious/*metabolism/microbiology/mortality, Bacterial Adhesion/*physiology, Bacterial Proteins/immunology/*physiology, Carrier Proteins/immunology/*physiology, Disease Models, Animal, Mice, Sepsis/*metabolism/microbiology, Streptococcus agalactiae/*pathogenicity/physiology, Virulence/genetics
Postens nummer:
Posten skapad:
2007-07-02 14:11
Posten ändrad:
2011-01-20 10:00

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