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Göteborgs universitets publikationer

Pentane-1,5-diol as a percutaneous absorption enhancer

Författare och institution:
Jan Faergemann (Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi); Björn Wahlstrand (Institutionen för invärtesmedicin, Avdelningen för klinisk farmakologi); Thomas Hedner (Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi); Jörgen Johnsson (-); R. H. Neubert (-); Lena Nyström (Institutionen för invärtesmedicin, Avdelningen för klinisk farmakologi); H. Maibach (-)
Publicerad i:
Arch Dermatol Res, 297 ( 6 ) s. 261-5
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Propylene glycol (propane-1,2-diol) is the only diol widely used in dermatology. Pentane-1,5-diol is mainly used as a plasticizer in cellulose products and adhesives, in dental composites and in brake fluid compositions and as a preservative for grain. However, pentane-1,5-diol is also an effective solvent, water-binding substance, antimicrobial agent and preservative and may therefore replace several ingredients in a skin composition. The release of tri-iodothyroacetic acid (TRIAC) and percutaneous absorption of hydrocortisone and mometasone furoate with either pentane-1,5-diol or propane-1,2-diol and 2-methyl-pentane-2,4-diol (hexylene glycol), respectively, as enhancers was compared. The release of TRIAC was 21% higher when pentane-1,5-diol was used as an enhancer instead of propane-1,2-diol. The percutaneous absorption of hydrocortisone through the skin was increased 12 times with propane-1,2-diol compared to 4.4 times with pentane-1,5-diol. However, the percutaneous absorption of hydrocortisone into the skin was 50% higher with pentane-1,5-diol compared to propane-1,2-diol. There was no significant difference, between the original mometasone furoate cream, with 2-methyl-pentane-2,4-diol, and the new cream with pentane-1,5-diol in the amount of mometasone furoate that was absorbed into the skin and through the skin. However, the cosmetic properties of the new mometasone furoate cream was superior to the original mometasone furoate cream, for examples, no bad odour, more even texture, goes better into the skin and has less greasiness. Pentane-1,5-diol can be used as a technology platform, which adds a series of desirable properties to dermatological preparations and enhances product usability. This will result in improved formulations for a series of major and commonly used dermatological drugs. When used in pharmaceutical topical preparations, pentane-1,5-diol will increase the percutaneous absorption of the active substance and it is an efficient antimicrobial agent that will act as an effective preservative in topical formulations. Pentane-1,5-diol is cosmetically attractive, has low risk for skin and eye irritation compared to other diols, low toxicity risk and no bad odour.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin ->
Dermatologi och venereologi
Administration, Cutaneous, Anti-Inflammatory Agents/administration & dosage, Chemistry, Pharmaceutical, Glycols/*pharmacology, Humans, Hydrocortisone/administration & dosage, Pregnadienediols/administration & dosage, Preservatives, Pharmaceutical/*pharmacology, Propylene Glycol/pharmacology, Skin Absorption/*drug effects, Solvents/*pharmacology, Triiodothyronine/analogs & derivatives/chemistry
Postens nummer:
Posten skapad:
2007-06-04 15:58
Posten ändrad:
2007-10-17 16:05

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