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Göteborgs universitets publikationer

PROPHECY—a yeast phenome database, update 2006

Författare och institution:
Luciano Fernandez-Ricaud (Institutionen för cell- och molekylärbiologi); Jonas Warringer (Institutionen för cell- och molekylärbiologi); Elke Ericson (Institutionen för cell- och molekylärbiologi); Kerstin Glaab (Institutionen för cell- och molekylärbiologi); Pär Davidsson (Institutionen för cell- och molekylärbiologi); Fabian Nilsson (Institutionen för cell- och molekylärbiologi); Graham J.L. Kemp (Institutionen för data- och informationsteknik, Datavetenskap, Bioinformatik (Chalmers), Chalmers); Olle Nerman (Institutionen för matematiska vetenskaper, matematisk statistik, Chalmers/GU); Anders Blomberg (Institutionen för cell- och molekylärbiologi)
Publicerad i:
Nucleic Acids Research, 35 s. D463-D467
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Connecting genotype to phenotype is fundamental in biomedical research and in our understanding of disease. Phenomics—the large-scale quantitative phenotypic analysis of genotypes on a genome-wide scale—connects automated data generation with the development of novel tools for phenotype data integration, mining and visualization. Our yeast phenomics database PROPHECY is available at Via phenotyping of 984 heterozygous diploids for all essential genes the genotypes analysed and presented in PROPHECY have been extended and now include all genes in the yeast genome. Further, phenotypic data from gene overexpression of 574 membrane spanning proteins has recently been included. To facilitate the interpretation of quantitative phenotypic data we have developed a new phenotype display option, the Comparative Growth Curve Display, where growth curve differences for a large number of mutants compared with the wild type are easily revealed. In addition, PROPHECY now offers a more informative and intuitive first-sight display of its phenotypic data via its new summary page. We have also extended the arsenal of data analysis tools to include dynamic visualization of phenotypes along individual chromosomes. PROPHECY is an initiative to enhance the growing field of phenome bioinformatics
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Biologiska vetenskaper ->
Bioinformatik och systembiologi
Postens nummer:
Posten skapad:
2007-04-02 11:23
Posten ändrad:
2010-01-26 10:52

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