transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Prodromal cognitive signs of dementia in 85-year-olds using four sources of information

Författare och institution:
S Sacuicu (-); Magnus Sjögren (-); Boo Johansson (Psykologiska institutionen); D Gustafsson (-); Ingmar Skoog (-)
Publicerad i:
Neurology, 65 ( 12 ) s. 1894-1900
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
The objective was to evaluate the utility of assessing four cognitive domains ob-tained from four information sources to identify individuals at risk for developing dementia, Alzheimer disease (AD), and vascular dementia (VaD). METHODS: A representative population sample of nondemented 85-year-olds (n = 313) from Gothenburg, Sweden, was examined regarding memory, language, and visuospa-tial and executive functions, using self- and key informant reports and neuropsy-chiatric and psychometric examinations. The sample was followed 3 years for in-cident dementia, AD, or possible VaD. RESULTS: All cases of dementia, AD, and VaD were preceded by low performance in most domains irrespective of informa-tion source. Isolated low memory performance or low cognitive performance with unimpaired memory did not predict dementia. Positive predictive values in-creased with number of domains affected. Self- and key informant reports were less useful for predicting dementia than neuropsychiatric and psychometric ex-aminations. The best positive predictive value (88%) was for low cognitive per-formance in all domains using neuropsychiatric and psychometric examinations; however, sensitivity was only 18%. CONCLUSIONS: Although memory impair-ment was necessary to predict dementia, it was not sufficient. Other cognitive domains needed to be affected. Relying on self-reports or key informants for early detection of dementia excluded a large group at risk. In addition, vascular de-mentia appeared to have a prodromal stage.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Cognition, dementia, elderly
Postens nummer:
Posten skapad:
2006-11-13 13:50
Posten ändrad:
2010-07-01 14:58

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007