transparent gif


Ej inloggad.

Göteborgs universitets publikationer

Inhibition of Wnt/beta-catenin signaling suppresses bleomycin-induced pulmonary fibrosis by attenuating the expression of TGF-beta 1 and FGF-2

Författare och institution:
X. Chen (-); C. W. Shi (-); X. N. Meng (-); K. J. Zhang (-); X. Y. Li (-); C. Wang (-); Zou Xiang (Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi); K. B. Hu (-); X. D. Han (-)
Publicerad i:
Experimental and Molecular Pathology, 101 ( 1 ) s. 22-30
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
Pulmonary fibrosis is a progressive lung disorder of unknown etiology, which is characterized by alterations in alveolar epithelium function, fibroblast activation, and increased extracellular matrix deposition. Recent studies have demonstrated that PF is associated with uncontrolled production of cytokines after lung injury. In the present study, we found that transforming growth factor-beta 1 (TGF-beta 1) and fibroblast growth factor 2 (FGF-2) were both upregulated in bleomycin-induced fibrotic lung tissue and primary murine alveolar epithelial Type II (ATII) cells treated with bleomycin. Furthermore, we discovered that TGF-beta 1 could induce the differentiation of lung resident mesenchymal stem cells (LR-MSCs) into fibroblasts, which may play an essential role in PF. LR-MSCs incubated with FGF-2 showed modest alterations in the expression of alpha-SMA and Vimentin. Moreover, in our study, we found that Wnt/beta-catenin signaling was activated both in vitro and in vivo as a result of bleomycin treatment. Interestingly, we also found that suppression of the Wnt/beta-catenin signaling could significantly attenuate bleomycin-induced PF accompanied with decreased expression of TGF-beta 1 and FGF-2 in vitro and in vivo. These results support that controlling the aberrant expression of TGF-beta 1 and FGF-2 via inhibition of Wnt/beta-catenin signaling could serve as a potential therapeutic strategy for PF. (C) 2016 Elsevier Inc. All rights reserved.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Biologiska vetenskaper
Alveolar epithelial type II cells (ATII cells), Lung resident mesenchymal stem cells (LR-MSCs), Transforming growth factor (TGF)-beta 1, Fibroblast growth factor (FGF)-2, Fibroblastic differentiation, mesenchymal stem-cells, alveolar epithelial-cells, growth-factor, tgf-beta, lung injury, transition, mice, differentiation, pathway, proliferation, Pathology
Postens nummer:
Posten skapad:
2016-09-26 12:51

Visa i Endnote-format

Göteborgs universitet • Tel. 031-786 0000
© Göteborgs universitet 2007