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Göteborgs universitets publikationer

Low serum vitamin D is associated with higher cortical porosity in elderly men

Författare och institution:
Daniel Sundh (Institutionen för medicin); Dan Mellström (Institutionen för medicin); O. Ljunggren (-); M. K. Karlsson (-); Claes Ohlsson (Institutionen för medicin); Martin Nilsson (Institutionen för medicin); Anna G Nilsson (Institutionen för medicin); Mattias Lorentzon (Institutionen för medicin)
Publicerad i:
J Intern Med,
1365-2796 (Electronic) 0954-6820 (Linking)
Artikel, refereegranskad vetenskaplig
Sammanfattning (abstract):
BACKGROUND: Bone loss at peripheral sites in the elderly is mainly cortical and involves increased cortical porosity. However, an association between bone loss at these sites and 25-hydroxyvitamin D has not been reported. OBJECTIVE: To investigate the association between serum levels of 25-hydroxyvitamin D, bone microstructure and areal bone mineral density (BMD) in elderly men. METHODS: A population-based cohort of 444 elderly men (mean +/- SD age 80.2 +/- 3.5 years) was investigated. Bone microstructure was measured by high-resolution peripheral quantitative computed tomography, areal BMD by dual-energy X-ray absorptiometry and serum 25-hydroxyvitamin D and parathyroid hormone levels by immunoassay. RESULTS: Mean cortical porosity at the distal tibia was 14.7% higher (12.5 +/- 4.3% vs. 10.9 +/- 4.1%, P < 0.05) whilst cortical volumetric BMD, area, trabecular bone volume fraction and femoral neck areal BMD were lower in men in the lowest quartile of vitamin D levels compared to the highest. In men with vitamin D deficiency (<25 nmol L-1 ) or insufficiency [25-49 nmol L-1 , in combination with an elevated serum level of parathyroid hormone (>6.8 pmol L-1 )], cortical porosity was 17.2% higher than in vitamin D-sufficient men (P < 0.01). A linear regression model including age, weight, height, daily calcium intake, physical activity, smoking vitamin D supplementation and parathyroid hormone showed that 25-hydroxyvitamin D independently predicted cortical porosity (standardized beta = -0.110, R2 = 1.1%, P = 0.024), area (beta = 0.123, R2 = 1.4%, P = 0.007) and cortical volumetric BMD (beta = 0.125, R2 = 1.4%, P = 0.007) of the tibia as well as areal BMD of the femoral neck (beta = 0.102, R2 = 0.9%, P = 0.04). CONCLUSION: Serum vitamin D is associated with cortical porosity, area and density, indicating that bone fragility as a result of low vitamin D could be due to changes in cortical bone microstructure and geometry.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
Klinisk medicin
cortical porosity, high-resolution peripheral computed tomography, vitamin D
Postens nummer:
Posten skapad:
2016-09-21 15:55

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